Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1α, MIP-1β, and eotaxin) in patients with atopic dermatitis
Enhanced production of CC-chemokines (RANTES, MCP-1, MIP-1α, MIP-1β, and eotaxin) in patients with atopic dermatitis
复制标题
DOI：
10.1007/s004030100230
复制
发表时间：
2001-07-01
影响因子：
3
通讯作者：
Sato, S
中科院分区：
文献类型：
--
作者：
Kaburagi, Y;Shimada, Y;Sato, S
CC-趋化因子是指导白细胞迁移至炎性病灶的有效分子。为了确定它们在与特应性皮炎（AD）相关的炎症中的作用，我们使用ELISA测定了AD患者的血清水平和外周血单核细胞（PBMC）自发产生的CC-趋化因子。与正常对照组（n = 22）相比，AD患者（n = 52）的RANTES、MCP-1、MIP-1 β和eotaxin血清水平升高。与正常对照组（n = 22）相比，AD患者（n = 19）血清RANTES、MCP-1和MIP-1 β水平升高。与正常对照组（n = 20）相比，AD患者（n = 39）和重度AD患者（n = 14）PBMC自发产生RANTES、MCP-1、MIP-1 α和MIP-1 β的能力增强。血清RANTES水平与血清总IgE水平、嗜酸性粒细胞数量和血清乳酸脱氢酶水平相关。我们的研究结果表明，CC-趋化因子的产生增加与AD相关的炎症相关。
CC-chemokines are potent molecules that direct the migration of leukocytes to inflammatory foci. To determine their role in inflammation associated with atopic dermatitis (AD), we determined serum levels and spontaneous production of CC-chemokines by peripheral blood mononuclear cells (PBMC) in AD patients using an ELISA. Serum levels of RANTES, MCP-1, MIP-1 beta, and eotaxin were increased in AD patients (n = 52) compared with normal controls (n = 22). Serum levels of RANTES, MCP-1, and MIP-1 beta were increased in AD patients with severe disease (n = 19) compared with normal controls (n = 22). Spontaneous production of RANTES, MCP-1, MIP-1 alpha and MIP-1 beta by PBMC was augmented in AD patients (n = 39) and in patients with severe AD (n = 14) compared with normal controls (n = 20). Serum RANTES levels correlated with total serum IgE levels, eosinophil numbers, and serum lactate dehydrogenase levels. Our results suggest that augmented production of CC-chemokines correlates with inflammation associated with AD.