ACUTE CHANGES IN CEREBRAL BLOOD-FLOW ASSOCIATED WITH MARIJUANA SMOKING
ACUTE CHANGES IN CEREBRAL BLOOD-FLOW ASSOCIATED WITH MARIJUANA SMOKING
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DOI：
10.1111/j.1600-0447.1989.tb08579.x
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发表时间：
1989-02-01
影响因子：
6.7
通讯作者：
TANT, SR
中科院分区：
文献类型：
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作者：
MATHEW, RJ;WILSON, WH;TANT, SR
在吸食高效大麻香烟和安慰剂大麻香烟之前和之后，使用 133 氙吸入技术测量有经验的 (ES) 和缺乏经验的 (IS) 大麻吸烟者的脑血流量 (CBF)。对照组在静息条件下测量两次 CBF。吸食大麻前后的情绪状态通过情绪状态概况 (POMS) 进行量化。吸食大麻后的 POMS 因素分析显示，IS 的焦虑增加，而 ES 的焦虑减少。 IS 的抑郁症也显着增加，活力下降，但 ES 中这两个变量都没有变化。吸食大麻后，IS 中的 CBF 下降，但 ES 中与 2 次对照运行相比，CBF 有所增加。在 IS 和 ES 中，服用安慰剂后的 CBF 变化与吸食大麻相关的变化相似。然而，在 IS 中，大麻引起的 CBF 降低显着高于安慰剂。 ES 中安慰剂和大麻后的 CBF 增加没有统计学上的显着差异。焦虑、愤怒、疲劳、困惑和抑郁与 CBF 呈显着负相关，而活力则呈正相关，但焦虑因素是唯一在半球 CBF 变化中占显着比例（部分相关）的因素。
Cerebral blood flow (CBF) was measured in experienced (ES) and inexperienced (IS) marijuana smokers with the 133xenon inhalation technique before and after smoking both a high-potency marijuana cigarette and a placebo marijuana cigarette. CBF was measured twice under resting conditions in a control group. Mood states before and after marijuana smoking were quantified with the Profile of Mood States (POMS). Analyses of POMS factors after smoking marijuana revealed IS had an increase in anxiety while ES had a decrease. IS also had a significant increase in depression and decrease in vigor, but neither variable changed in the ES. After marijuana, CBF decreased in IS, but in ES, it increased in comparison with the 2 control runs. In both IS and ES, CBF changes following placebo administration were similar to those associated with marijuana smoking. However, in IS, the marijuana-induced CBF decrease was significantly higher than that associated with placebo. There were no statistically significant differences between the CBF increase seen after placebo and marijuana in ES. Anxiety, anger, fatigue, confusion and depression had significant negative correlations with CBF while vigor correlated positively, but the anxiety factor was the only one to account for a significant percentage of the change (partial correlation) in hemispheric CBF.