Seasonal patterns of initiating antidepressant therapy in general practice in the Netherlands during 2002-2007
Seasonal patterns of initiating antidepressant therapy in general practice in the Netherlands during 2002-2007
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DOI：
10.1016/j.jad.2009.06.033
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发表时间：
2010-05-01
影响因子：
6.6
通讯作者：
Heerdink, Eibert R.
中科院分区：
文献类型：
--
作者：
Gardarsdottir, Helga;Egberts, Toine C. G.;Heerdink, Eibert R.
背景抗抑郁药处方的季节性研究显示，秋季和冬季是处方高峰期。从那时起，新的抗抑郁药已经上市，适应症也有所扩大，可能导致处方实践的变化这项研究调查了2002年期间在一般实践中开始使用抗抑郁药的季节性模式，方法数据来自荷兰全科医学信息网。研究人群由2001年12月21日至2007年12月20日开始使用抗抑郁药的成年患者组成。2007年，在开始使用抗抑郁药之前至少两年内没有使用抗抑郁药。调查了四个季节开始使用抗抑郁药的季节分布。使用卡方检验对季节之间开始使用频率的差异进行了检验，标准化为一般实践接触。16 289例为女性（64 0%），平均年龄10岁（标准差（SD））50 5（18 0）年（p <001），冬季开始使用的患者比夏季多约5-35%（p <001）在所有患者组中均观察到开始使用抗抑郁药的季节性，18-30岁及以上年龄组除外60年的局限性我们的研究只调查了全科医生的处方，因此遗漏了精神科医生的其他处方。结论季节性影响抗抑郁药的使用并没有随着新的抗抑郁药的引入而改变，符合抑郁症发作的季节性，大多数患者在冬季开始使用，夏季最少（C）2009 Elsevier B V保留所有权利
Background Studies on seasonality in antidepressant prescribing showed prescribing peaks during autumn and winter Since then, new antidepressants have become available and indications have broadened, possibly contributing to a change in prescribing practices This study investigates seasonal patterns of initiating antidepressant use in general practice during 2002-2007 in the NetherlandsMethod Data were obtained from the Netherlands Information Network of General Practice The study population was composed of adult patients initiating antidepressant use from 21 December 2001 to 20 December 2007, with no antidepressant use during at least two years prior to initiation Seasonal distribution of initiating antidepressant use was investigated for the four seasons The difference in frequency of initiating use between the seasons, normalized for general practice contacts, was tested using Chi-square testingResults The majority of the study population (N = 16,289) was female (64 0%) with a mean age (standard deviation (SD)) of 50 5 (18 0) years Significant seasonal variation (p < 0 01) was found in initiation of antidepressant use, with about 5-35% more patients initiating use during winter than summer Significant (p < 0 01) seasonality of initiating antidepressant use was seen in all patient groups, except within age groups 18-30 years and >60 yearsLimitations Our study investigated only general practitioner prescribing thus additional prescriptions from psychiatrists are missedConclusions The seasonal influence on initiation of antidepressant drug use has not changed with the introduction of the newer antidepressants and is in line with seasonality of depression onset, with most patients initiating use during the winter and fewest during the summer (C) 2009 Elsevier B V All rights reserved