Epithelial induction in dermatofibroma: a role for the epidermal growth factor (EGF) receptor.
Epithelial induction in dermatofibroma: a role for the epidermal growth factor (EGF) receptor.
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皮肤纤维瘤中的上皮诱导：表皮生长因子（EGF）受体的作用。
DOI：
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发表时间：
1997
影响因子：
1.1
通讯作者：
M. Everett
中科院分区：
文献类型：
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作者：
M. Morgan;H. Howard;M. Everett
皮肤纤维瘤是指一系列坚硬、结节状、无包膜的病变，常发生于四肢。组织学上，DF由梭形细胞组成，向组织细胞和血管成分分化，通常与上皮增生和基底角化细胞色素沉着相关，组织学上可能模拟基底细胞癌（BCC）。特征性上皮变化可能是间充质介导的，并可能代表宿主的修复反应，也称为诱导现象。表皮-间充质细胞相互作用，包括诱导，发生在胚胎皮肤发育的各个阶段，并对组织修复的损伤作出反应。细胞相互作用由细胞的直接并置或由细胞（自分泌效应）或邻近细胞（旁分泌效应）直接产生的可溶性蛋白质激素介导。其中重要的可溶性介质是表皮生长因子（EGF），已知其刺激多种转化和良性组织的增殖和分化。我们研究了表皮生长因子受体（EGF-R）的表达和上皮细胞诱导之间可能的病因学关联，在一个前瞻性系列的20例DF相比，实体，如颗粒细胞瘤，瘢痕组织，和皮脂痣同样显示上皮增生。表皮生长因子受体的免疫组化染色显示，在每一个DF病例中，树突状梭形细胞和过度增生的角质形成细胞都有强烈的真皮染色。EGF-R的免疫组化染色在颗粒细胞瘤（n = 3），皮脂痣（n = 6）和瘢痕组织（n = 12）的所有真皮部位均不存在。
Dermatofibroma (DF) refers to a spectrum of firm, nodular, nonencapsulated lesions that occur commonly on the extremities. Histologically, DF is composed of spindle cells with variable differentiation toward histiocytic and vascular elements, often associated with epithelial hyperplasia and basilar keratinocyte pigmentation that histologically may simulate basal cell carcinoma (BCC). The characteristic epithelial changes are likely to be mesenchyma-mediated and probably represent a host reparative response otherwise known as the inductive phenomenon. Epidermal-mesenchymal cellular interactions, including induction, occur in various stages of embryonic skin development and in response to injury with tissue repair. Cellular interaction is mediated by direct apposition of cells or by soluble protein hormones produced directly by the cell (autocrine effect) or adjacent cells (paracrine effect). Among the important soluble mediators are epidermal growth factor (EGF), which is known to stimulate the proliferation and differentiation of a variety of transformed and benign tissues. We investigated the possible etiologic association between EGF receptor (EGF-R) expression and epithelial induction in a prospective series of 20 cases of DF compared to entities such as granular cell tumor, scar tissue, and nevus sebaceus similarly showing epithelial hyperplasia. Immunohistochemical staining for EGF-R showed strong dermal staining of dendritic spindle cells and overlying hyperplastic keratinocytes in each of the DF cases. Immunohistochemical staining for EGF-R was absent within all dermal loci of granular cell tumor (n = 3), nevus sebaceus (n = 6), and scar tissue (n = 12).