Men who have sex with men more often chose daily than event-driven use of pre-exposure prophylaxis: baseline analysis of a demonstration study in Amsterdam.
Men who have sex with men more often chose daily than event-driven use of pre-exposure prophylaxis: baseline analysis of a demonstration study in Amsterdam.
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DOI：
10.1002/jia2.25105
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发表时间：
2018-03
影响因子：
6
通讯作者：
Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative
中科院分区：
文献类型：
--
作者：
Hoornenborg E;Achterbergh RC;van der Loeff MFS;Davidovich U;van der Helm JJ;Hogewoning A;van Duijnhoven YT;Sonder GJ;de Vries HJ;Prins M;Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam Initiative
阿姆斯特丹PrEP项目是一项在大型性传播感染（STI）诊所进行的前瞻性开放标签示范研究。我们检查了PrEP的吸收;与男性发生性关系的男性（MSM）和开始PrEP的跨性别者的基线特征;他们对日常与事件驱动PrEP的选择以及这些选择的决定因素。从2015年8月到2016年5月，在荷兰阿姆斯特丹公共卫生服务的STI诊所进行登记。男男性行为者或变性人如果在过去六个月内至少有一个感染艾滋病毒的危险因素，则有资格参加。参与者可以选择每日或事件驱动使用替诺福韦/恩曲他滨。使用描述性统计分析基线数据，并采用多变量分析确定与每日与事件驱动PrEP相关的变量。870人提交了在线申请，其中587人被邀请进行筛选访视。其中，415人接受了合格性筛查，376人启动了PrEP。四分之一（103/376，27%）选择了事件驱动的PrEP。细菌性传播感染的患病率为19.0%，前三个月的平均无安全套肛交（CAS）事件为11次。在多变量分析中，（≥45 vs. ≤34，aOR 2.1，95% CI 1.2 - 3.9），涉及稳定关系（aOR 1.7，95% CI 1.0 - 2.7），未使用其他每日药物（aOR 0.6，95% CI 0.3 - 0.9），CAS发作次数较少（每对数增加aOR 0.7，95% CI 0.6至0.9）是选择事件驱动PrEP的决定因素。PrEP计划正在成为更重要的干预策略之一，其目标是减少由于HIV感染事件，我们无法容纳许多申请参加本研究的人员。为PrEP用户提供给药方案的选择可能会使艾滋病毒预防策略进一步个性化，并提高摄取率，依从性和成本效益。大多数参与者更喜欢每日使用而不是事件驱动使用。在这大多数人中，报告了PrEP开始前大量的CAS事件，我们观察到STI的高患病率。选择事件驱动PrEP的决定因素是年龄较大，CAS发作较少，没有其他日常药物使用，并且涉及稳定的关系。
The Amsterdam PrEP project is a prospective, open‐label demonstration study at a large sexually transmitted infection (STI) clinic. We examined the uptake of PrEP; the baseline characteristics of men who have sex with men (MSM) and transgender persons initiating PrEP; their choices of daily versus event‐driven PrEP and the determinants of these choices. From August 2015 through May 2016, enrolment took place at the STI clinic of the Public Health Service of Amsterdam, the Netherlands. MSM or transgender persons were eligible if they had at least one risk factor for HIV infection within the preceding six months. Participants were offered a choice between daily or event‐driven use of tenofovir/emtricitabine. Baseline data were analysed using descriptive statistics and multivariable analysis was employed to determine variables associated with daily versus event‐driven PrEP. Online applications were submitted by 870 persons, of whom 587 were invited for a screening visit. Of them, 415 were screened for eligibility and 376 initiated PrEP. One quarter (103/376, 27%) chose event‐driven PrEP. Prevalence of bacterial STI was 19.0% and mean condomless anal sex (CAS) episodes in the preceding three months were 11. In multivariable analysis, older age (≥45 vs. ≤34, aOR 2.1, 95% CI 1.2 to 3.9), being involved in a steady relationship (aOR 1.7, 95% CI 1.0 to 2.7), no other daily medication use (aOR 0.6, 95% CI 0.3 to 0.9), and fewer episodes of CAS (per log increase aOR 0.7, 95% CI 0.6 to 0.9) were determinants for choosing event‐driven PrEP. PrEP programmes are becoming one of the more important intervention strategies with the goal of reducing incident HIV‐infection and we were unable to accommodate many of the persons applying for this study. Offering a choice of dosing regimen to PrEP users may enable further personalization of HIV prevention strategies and enhance up‐take, adherence and cost‐effectiveness. The majority of participants preferred daily versus event‐driven use. Within this majority, a high number of CAS episodes before PrEP initiation was reported and we observed a high prevalence of STI. Determinants of choosing event‐driven PrEP were older age, fewer CAS episodes, no other daily medication use, and involved in a steady relationship.
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DOI：
10.1097/qad.0000000000001627
发表时间：
2017-10-23
期刊：
AIDS (London, England)
影响因子：
--
作者：
Hoornenborg E;Krakower DS;Prins M;Mayer KH
通讯作者：
Mayer KH
影响因子：
3.8
作者：
Fonner, Virginia A.;Dalglish, Sarah L.;Grant, Robert M.
通讯作者：
Grant, Robert M.
影响因子：
39
作者：
Liu, Albert Y.;Cohen, Stephanie E.;Vittinghoff, Eric;Anderson, Peter L.;Doblecki-Lewis, Susanne;Bacon, Oliver;Chege, Wairimu;Postle, Brian S.;Matheson, Tim;Amico, K. Rivet;Liegler, Teri;Rawlings, M. Keith;Trainor, Nikole;Blue, Robert Wilder;Estrada, Yannine;Coleman, Megan E.;Cardenas, Gabriel;Feaster, Daniel J.;Grant, Robert;Philip, Susan S.;Elion, Richard;Buchbinder, Susan;Kolber, Michael A.
通讯作者：
Kolber, Michael A.
DOI：
10.1097/qai.0000000000001129
发表时间：
2016-12-15
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Marcus JL;Hurley LB;Hare CB;Nguyen DP;Phengrasamy T;Silverberg MJ;Stoltey JE;Volk JE
通讯作者：
Volk JE
影响因子：
3.8
作者：
Grov, Christian;Parsons, Jeffrey T.;Bimbi, David S.
通讯作者：
Bimbi, David S.