Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD
Longitudinal MRI study of hippocampal volume in trauma survivors with PTSD
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DOI：
10.1176/appi.ajp.158.8.1248
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发表时间：
2001-08-01
影响因子：
17.7
通讯作者：
Shalev, AY
中科院分区：
文献类型：
--
作者：
Bonne, O;Brandes, D;Shalev, AY
目的：作者前瞻性地探讨了是否减少海马体积发生在最近的创伤幸存者谁开发创伤后应激障碍（PTSD）。方法：37创伤事件的幸存者进行了评估，在一周内的创伤事件和6个月后。评估包括大脑磁共振成像（包括124个1.5 mm厚的冠状切片），心理测量测试和结构化临床访谈。临床医生管理的PTSD量表授予PTSD诊断在6 months.Results：10名受试者（27%）有PTSD在6个月。在1周或6个月时，患有PTSD的受试者与没有PTSD的受试者在海马体积（右侧或左侧）方面没有差异。有没有减少海马体积的PTSD科目之间的1周和6 months.Conclusions：海马体积较小是不是一个必要的风险因素发展PTSD，并没有发生在6个月内表达的障碍。这种大脑异常可能发生在慢性或复杂的PTSD患者中。
Objective: The authors prospectively explored whether a reduction in the volume of the hippocampus occurs in recent trauma survivors who develop posttraumatic stress disorder (PTSD).Method: Thirty-seven survivors of traumatic events were assessed within a week of the traumatic event and 6 months later. The assessment included magnetic resonance imaging of the brain (including 124 coronal slices of 1.5-mm thickness), psychometric testing, and structured clinical interviews. The Clinician-Administered PTSD Scale conferred PTSD diagnoses at 6 months.Results: Ten subjects (27%) had PTSD at 6 months. The subjects with PTSD did not differ from those without PTSD in hippocampal volume (right or left) at 1 week or 6 months. There was no reduction in hippocampal volume in the PTSD subjects between 1 week and 6 months.Conclusions: Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder. This brain abnormality might occur in individuals with chronic or complicated PTSD.