Explicit memory performance in infants of diabetic mothers at 1 year of age
Explicit memory performance in infants of diabetic mothers at 1 year of age
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DOI：
10.1017/s0012162205001039
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发表时间：
2005-08-01
影响因子：
3.8
通讯作者：
Nelson, CA
中科院分区：
文献类型：
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作者：
DeBoer, T;Wewerka, S;Nelson, CA
本研究旨在探讨异常胎儿环境对外显记忆表现的影响。基于动物模型，假设糖尿病母亲（IDMs）的婴儿由于暴露于多种神经危险因素（包括慢性缺氧，高血糖/反应性低血糖和缺铁）而经历记忆表现的扰动。通过诱导/延迟模仿范式，比较了13名idm儿童（7名女性，6名男性，平均年龄365天，SD 11）和16名正常发育儿童（7名女性，9名男性，平均年龄379天，SD 9）的记忆表现。与对照组（平均胎龄40w， SD 1；平均出生体重3639g， SD 348；平均新生儿铁蛋白浓度140 μ g/L， SD 46）相比，IDM组胎龄较短（平均38w， SD 2），标准化出生体重评分较高（平均3797g， SD 947），铁储量较低（平均铁蛋白浓度87 μ g/L， SD 68）。在统计上控制了胎龄和整体认知能力后，idm显示出在延迟后回忆多步骤事件序列的能力缺陷。这些发现强调了产前环境对随后的记忆行为的重要性，并表明产前代谢异常、记忆、电路发育和行为记忆表现之间存在联系。
The aim of the present research was to investigate the impact of abnormal fetal environment on explicit memory performance. Based on animal models, it was hypothesized that infants of diabetic mothers (IDMs) experience perturbations in memory performance due to exposure to multiple neurologic risk factors including: chronic hypoxia, hyperglycemia/reactive hypoglycemia, and iron deficiency. Memory performance, as measured by the elicited/deferred imitation paradigm, was compared between 13 IDMs (seven females, six males; mean age 365 days, SD 11) and 16 typically developing children (seven females, nine males; mean age 379 days, SD 9). The IDM group was characterized by shorter gestational age (mean 38w, SD 2), greater standardized birthweight scores (mean 3797g, SD 947), and lower iron stores (mean ferritin concentration 87 mu g/L, SD 68) in comparison with the control group (mean gestational age: 40w, SD 1; mean birthweight: 3639g, SD 348; mean newborn ferritin concentration 140 mu g/L, SD 46). After statistically controlling for both gestational age and global cognitive abilities, IDMs demonstrated a deficit in the ability to recall multi-step event sequences after a delay was imposed. These findings highlight the importance of the prenatal environment on subsequent mnemonic behavior and suggest a connection between metabolic abnormalities during the prenatal period, development of memory, circuitry, and behavioral mnemonic performance.