Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression
Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression
复制标题
小鼠乳腺肿瘤的整体表达谱和通路分析揭示了乳腺癌进展中菌株和阶段特异性失调通路
DOI：
10.1080/15384101.2018.1442629
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发表时间：
2018-01-01
期刊：
影响因子：
4.3
通讯作者：
Qian, Chao-Nan
中科院分区：
文献类型：
--
作者：
Mei, Yan;Yang, Jun-Ping;Qian, Chao-Nan
ABSTRACT It is believed that the alteration of tissue microenvironment would affect cancer initiation and progression. However, little is known in terms of the underlying molecular mechanisms that would affect the initiation and progression of breast cancer. In the present study, we use two murine mammary tumor models with different speeds of tumor initiation and progression for whole genome expression profiling to reveal the involved genes and signaling pathways. The pathways regulating PI3K-Akt signaling and Ras signaling were activated in Fvb mice and promoted tumor progression. Contrastingly, the pathways regulating apoptosis and cellular senescence were activated in Fvb.B6 mice and suppressed tumor progression. We identified distinct patterns of oncogenic pathways activation at different stages of breast cancer, and uncovered five oncogenic pathways that were activated in both human and mouse breast cancers. The genes and pathways discovered in our study would be useful information for other researchers and drug development.
