Penicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: Facts, doubts and hopes
Penicillin-binding proteins. Wall peptidoglycan assembly and resistance to penicillin: Facts, doubts and hopes
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DOI：
10.1016/s0924-8579(96)00358-5
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发表时间：
1997-02-01
影响因子：
10.8
通讯作者：
Ghuysen, JM
中科院分区：
文献类型：
--
作者：
Ghuysen, JM
细菌细胞壁肽聚糖的组装依赖于一种现成的前体，即脂类II中间体的可用性。这种中间体由一个多功能工厂负责，该工厂提供在质膜外部组装聚合物所需的酶活性。形态发生网络以细胞周期依赖的方式调节合成。由于细胞机械的基本组件是β-内酰胺类抗生素的靶标，因此安全装置可以保护细胞免受这些有毒物质的伤害。争论和共识的形成是科学研究的核心。这篇综述着重于细菌细胞壁生物化学家仍在努力回答的问题，并取得了越来越多的成功。(C)1997年爱思唯尔科学公司。
The assembly of the bacterial cell wall peptidoglycan relies upon the availability of a ready-made precursor, the lipid II intermediate. This intermediate is taken up by a multifunctional factory that provides the required enzymatic activities for polymer assembly at the exterior of the plasma membrane. Morphogenetic networks regulate the synthesis in a cell-cycle-dependent fashion. As essential components of the cell machinery are targets of beta-lactam antibiotics, safety devices protect the cells against these toxic agents. Controversy and consensus formation lie at the heart of the scientific research. This review focuses on questions that bacterial cell wall biochemists still strive, with increasing success, to answer. (C) 1997 Elsevier Science B.V.