DIETARY-INDUCED OBESITY - EFFECT OF DIETARY FATS ON ADIPOSE-TISSUE CELLULARITY IN MICE
DIETARY-INDUCED OBESITY - EFFECT OF DIETARY FATS ON ADIPOSE-TISSUE CELLULARITY IN MICE
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DOI：
10.1079/bjn19830006
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发表时间：
1983-01-01
影响因子：
3.6
通讯作者：
LEMONNIER, D
中科院分区：
文献类型：
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作者：
BOURGEOIS, F;ALEXIU, A;LEMONNIER, D
4周龄的雄性和雌性小鼠分别饲喂含有不同量猪油（0 ~ 300 g/kg）或不同种类饲粮脂肪（300 g/kg）的自由饲料13周。用组织学方法测定3个不同脂肪部位的脂肪细胞数量和大小。饲粮中添加200 g/kg的猪油（43%的能量来自脂肪）足以促进参数脂肪中脂肪细胞的增生。男性皮下脂肪也有增生。脂肪细胞肥大与饮食中猪油含量之间的关系依赖于部位和性别。无论食用哪种脂肪，如猪油、牛油、葵花籽油或大豆油，都会导致肥胖。饲喂猪油的雄鼠皮下脂肪细胞增大，脂肪细胞数量增多，而饲喂大豆油的雄鼠皮下脂肪细胞肥大。在雌性小鼠组中，脂肪细胞增生或肥大，或两者兼而有之，与脂肪部位有关，而与膳食脂肪的种类无关。不同来源的膳食脂肪可诱导小鼠肥胖。脂肪组织细胞的影响取决于所吃脂肪的水平和种类、脂肪部位和性别。
Male and female mice, 4 wk old, were fed ad lib diets containing various amounts of lard (0-300 g/kg) or various kinds of dietary fats (300 g/kg) for 13 wk. Fat cell number and size were determined by a histological method in 3 different adipose sites. Lard at 200 g/kg diet (43% energy from lipids) was sufficient to promote fat cell hyperplasia in the parametrial fat. Hyperplasia was also observed in the subcutaneous fat in males. The relationship between fat cell hypertrophy and the level of lard in the diet was dependent on site and sex. Obesity was produced whatever the kind of dietary fat eaten: lard, beef tallow, sunflower oil or soya-bean oil. In the subcutaneous depot of males given lard, fat cell size and number were increased, but only cell hypertrophy was observed in those given soya-bean oil. In the female groups of mice fat cell hyperplasia or hypertrophy, or both, were related to adipose site but not to the kind of dietary fat. Dietary fats of different origin can induce obesity in mice. The effects of adipose tissue cellularity depend on the levels and kind of fat eaten, the adipose site and sex.