A new quinolone alkaloid from the fruits of Tetradium ruticarpum
A new quinolone alkaloid from the fruits of Tetradium ruticarpum
复制标题
一种来自黄果木果实的新喹诺酮生物碱
DOI：
10.1080/14786419.2019.1624954
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发表时间：
2019-07-03
影响因子：
2.2
通讯作者：
Wang, Qi-Zhi
中科院分区：
文献类型：
--
作者：
Chen, Ma;Liu, Xiao;Wang, Qi-Zhi
摘要从四合木果实中分离得到一种侧链不饱和度为3度的新型喹诺酮类生物碱，命名为1-甲基-2-[(6Z,9Z,12Z)-6,9,12- pentadecadiene]-4(1H)-喹诺酮(1)，以及已知的3种喹诺酮类生物碱：1-甲基-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-喹诺酮(2)、1-甲基-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-喹诺酮(3)、1-甲基-2-[(Z)-8-tridecenyl]-4(1H)-喹诺酮(4)。T.G.Hartley。通过理化性质和光谱数据对其结构进行了表征。96孔微孔板MTT法测定了化合物对3种人肿瘤细胞系Lovo、MDA-MB-231、HeLa细胞的细胞毒活性，化合物1对MDA-MB-231细胞的IC50值为7.95 μM。图形抽象
Abstract A rare new quinolone alkaloid containing three degrees of unsaturation in the side chain, named as 1-methyl-2-[(6Z,9Z,12Z)-6,9,12-pentadecatriene]-4(1H)-quinolone (1), together with three known quinolone alkaloids 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (2), 1-methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone (3), 1-methyl-2-[(Z)-8-tridecenyl]-4(1H)-quinolone (4), were isolated from the fruits of Tetradium ruticarpum (A.Juss.) T.G.Hartley. Their structures were elucidated by physicochemical properties and spectroscopic data. All compounds were evaluated for their cytotoxic activities against three human tumor cell lines, including Lovo, MDA-MB-231, HeLa cells, by MTT method in 96-well microplates, and compounds 1 exhibited potent activity against MDA-MB-231 cells with IC50 values of 7.95 μM. GRAPHICAL ABSTRACT