Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney:: a population-based study
Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney:: a population-based study
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DOI：
10.1016/s0140-6736(98)06099-1
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发表时间：
1999-02-27
期刊：
影响因子：
168.9
通讯作者：
Steineck, G
中科院分区：
文献类型：
--
作者：
Augustsson, K;Skog, K;Steineck, G
研究背景熟肉和鱼肉中的杂环胺在动物模型中具有致癌性，在人体中可形成DNA加合物。我们进行了一项研究，以评估这些物质是否与大肠癌和泌尿道癌的风险有关。方法在一项以人群为基础的病例对照研究中，从瑞典癌症登记处确定病例。对照组从人口登记册中随机选择。各种食物的摄入量的信息，并通过问卷调查进行评估，在不同温度下烹饪的食物的照片。我们测量了在这些conditions.Findings的杂环胺的含量在这些条件下烹饪的食物中检索到的信息从553个对照组，352例结肠癌，249例直肠癌，273例膀胱癌，138例肾癌。对照组的应答率为80%，病例组为70%。估计每日摄入的杂环胺的中位数为77纳克的控制，和66纳克，63纳克，96纳克，和84纳克的情况下，结肠癌，直肠癌，膀胱癌和肾癌，分别。摄入杂环胺的相对风险（最高与最低五分位数）为结肠癌0.6（95% CI 0.4-1.0），直肠癌0.7（0.4-1.1），膀胱癌1.2（0.7-2.1），肾癌1.0（0.5-1.9）。7例，但没有控制，估计每天摄入的杂环胺超过1900 ng.Interpretation摄入的杂环胺，在本研究人群的通常饮食范围内，是不太可能增加癌症的发病率在结肠，直肠，膀胱，或肾脏。对于超过1900 ng的每日摄入量，我们的数据与人类致癌性一致，但精确度极低。
Background Heterocyclic amines formed in cooked meat and fish are carcinogenic in animal models and form DNA adducts in human beings. We undertook a study to assess whether these substances are related to the risks of cancer in the large bowel and urinary tract.Methods In a population-based case-control study, cases were identified from the Swedish cancer registry. Controls were randomly selected from the population register. Information on intake of various foods and was assessed by questionnaire, with photographs of foods cooked at various temperatures. We measured the content of heterocyclic amines in foods cooked under these conditions.Findings Information was retrieved from 553 controls, 352 cases of colon cancer, 249 cases of rectal cancer, 273 cases of bladder cancer, and 138 cases of kidney cancer. The response rate was 80% for controls and 70% for cases. The estimated daily median intake of heterocyclic amines was 77 ng for controls, and 66 ng, 63 ng, 96 ng, and 84 ng for cases with cancer of the colon, rectum, bladder, and kidney, respectively. The relative risk for the intake of heterocyclic amines (highest vs lowest quintile) was 0.6 (95% CI 0.4-1.0) for colon cancer, 0.7 (0.4-1.1) for rectal cancer, 1.2 (0.7-2.1) for bladder cancer, and 1.0 (0.5-1.9) for kidney cancer. Seven cases, but no controls, had an estimated daily intake of heterocyclic amines above 1900 ng.Interpretation Intake of heterocyclic amines, within the usual dietary range in this study population, is unlikely to increase the incidence of cancer in the colon, rectum, bladder, or kidney. For daily intakes above 1900 ng, our data are consistent with human carcinogenicity, but the precision was extremely low.