The voltage-dependent anion channel: an essential player in apoptosis
The voltage-dependent anion channel: an essential player in apoptosis
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DOI：
10.1016/s0300-9084(02)01370-6
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发表时间：
2002-02-01
期刊：
影响因子：
3.9
通讯作者：
Shimizu, S
中科院分区：
文献类型：
--
作者：
Tsujimoto, Y;Shimizu, S
线粒体膜外膜通透性的增加是细胞凋亡性死亡的一个中心事件，因为它向细胞质中释放了几种促凋亡因子，如细胞色素c，从而激活了下游的破坏过程。电压依赖性阴离子通道(VDAC或线粒体孔蛋白)在线粒体膜通透性增加中起重要作用，并受Bcl2家族蛋白的直接相互作用调节。抗凋亡的Bcl2家族成员关闭VDAC，而一些(但不是所有)促凋亡成员与VDAC相互作用，产生细胞色素c通过的蛋白质传导通道，尽管VDAC直接参与线粒体膜通透性的凋亡增加，并被认为是通透性转换孔复合体的组成部分，但其在外膜通透性调节中的作用可以与通透性转换事件的发生分开，如线粒体肿胀和外膜破裂。VDAC不仅与Bcl2家族成员相互作用，还与其他蛋白质相互作用，可能是多种生死信号的汇聚点。(C)2002年，法国生物科学与生物学家学会/爱思唯尔科学与医学学会。版权所有。
The increase of outer mitochondrial membrane permeability is a central event in apoptotic cell death, since it releases several apoptogenic factors such as cytochrome c into the cytoplasm that activate the downstream destructive processes. The voltage-dependent anion channel (VDAC or mitochondrial porin) plays an essential role in the increase of mitochondrial membrane permeability, and it is regulated by the Bcl-2 family of proteins via direct interaction. Anti-apoptotic Bcl-2 family members close the VDAC, whereas some (but not all) pro-apoptotic members interact with the VDAC to generate a protein-conducting channel through which cytochrome c can pass, Although the VDAC is directly involved in the apoptotic increase of mitochondrial membrane permeability and is known to be a component of the permeability transition pore complex, its role in the regulation of outer membrane permeability can be separated from the occurrence of permeability transition events, such as mitochondrial swelling followed by rupture of the outer mitochondrial membrane. The VDAC not only interacts with Bcl-2 family members, but also with other proteins, and probably acts as a convergence point for a variety of life-or-death signals. (C) 2002 Societe francaise de biochimie et biologie moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.