Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1G93A G1H mouse model of familial amyotrophic lateral sclerosis
Behavioural and anatomical effects of systemically administered leukemia inhibitory factor in the SOD1G93A G1H mouse model of familial amyotrophic lateral sclerosis
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DOI：
10.1016/s0006-8993(03)02989-5
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发表时间：
2003-08-22
期刊：
影响因子：
2.9
通讯作者：
Cheema, SS
中科院分区：
文献类型：
--
作者：
Azari, MF;Lopes, EC;Cheema, SS
我们研究了家族性ALS SOD1（G93A G1H）小鼠模型每天腹腔注射25杯/kg LIF的解剖学和行为学影响。我们发现在LIF治疗的小鼠中有一些微妙的有益行为变化。其中包括由临床评分确定的女性临床疾病发病较晚；男性握力更强；以及通过旋转测试确定的男性运动障碍的延迟发展。然而，在这些小鼠中，我们没有发现这种全身剂量的LIF对运动神经元的显著拯救或延长生存的结果。(C) 2003 Elsevier B.V.版权所有
We investigated the anatomical and behavioural effects of daily intraperitoneal injection of 25 mug/kg of LIF in the SOD1(G93A G1H) mouse model of familial ALS. We found some subtle beneficial behavioural changes in LIF treated mice. These included later onset of clinical disease in females as determined by clinical scoring; better grip strength in males; and delayed development of motor impairment in males as determined by the rotarod test. However, we found no significant rescue of motoneurons or prolongation of survival as a result of this systemic dose of LIF in these mice. (C) 2003 Elsevier B.V. All rights reserved.