Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli Arabs
Mitochondrial DNA HV lineage increases the susceptibility to schizophrenia among Israeli Arabs
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DOI：
10.1016/j.schres.2007.04.020
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发表时间：
2007-08-01
影响因子：
4.5
通讯作者：
Mishmar, Dan
中科院分区：
文献类型：
--
作者：
Amar, Shirly;Shamir, Alon;Mishmar, Dan
单倍型和单倍群是一组相互关联的常见 DNA 变体，充当复杂疾病的易感性或保护性因素。越来越多的证据表明线粒体生物能功能障碍导致精神分裂症表型。我们研究了精神分裂症患者的线粒体 DNA 单倍群。由于线粒体是从母亲那里继承的，我们使用健康的父亲作为理想的病例对照组。对精神分裂症患者与其健康父亲（202对）相比线粒体单倍群的分布进行分析，结果发现患者中mtDNA谱系簇RV的过度表达（p=0.01），相对风险（比值比）增加为1.8。由于线粒体 DNA 相对于核 DNA 较小，因此可以以无假设的方式进行总线粒体基因组分析。然而，线粒体 DNA 单倍群在人群中差异很大，因此有必要在其他人类种族群体中复制我们的结果。 (c) 2007 Elsevier B.V. 保留所有权利。
Haplotypes and haplogroups are linked sets of common DNA variants, acting as susceptibility or protective factors to complex disorders. Growing evidence suggests that dysfunction of mitochondrial bioenergetics contributes to the schizophrenia phenotype. We studied mitochondrial DNA haplogroups in schizophrenia patients. Since mitochondria are inherited from the mothers, we used healthy fathers as an ideal case-control group.Analysis of the distribution of mitochondrial haplogroups in schizophrenia patients compared to their healthy fathers (202 pairs) resulted in an over-representation of the mtDNA lineage cluster, RV, in the patients (p=0.01), with increased relative risk (odds ratio) of 1.8. Since mitochondrial DNA is small relative to nuclear DNA, a total mitochondrial genome analysis was possible in a hypothesis-free manner. However, mitochondrial DNA haplogroups are highly variable in human population and it will be necessary to replicate our results in other human ethnic groups. (c) 2007 Elsevier B.V. All rights reserved.