The Role of Exosomes in Pancreatic Cancer Microenvironment
The Role of Exosomes in Pancreatic Cancer Microenvironment
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DOI：
10.1007/s11538-017-0254-9
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发表时间：
2018-05-01
影响因子：
3.5
通讯作者：
Hao, Wenrui
中科院分区：
文献类型：
--
作者：
Friedman, Avner;Hao, Wenrui
外泌体是细胞脱落的纳米囊泡，是细胞与其他细胞交流的一种手段。外泌体包含mrna、microrna （miRs）和功能蛋白。在本文中，我们利用胰腺癌细胞和树突状细胞脱落的外泌体建立了肿瘤-免疫相互作用的数学模型。癌细胞的外泌体含有促进其增殖和抑制树突状细胞、CD4+和CD8+ T细胞免疫反应的miRs。树突状细胞释放带有诱导癌细胞凋亡和阻断调节性T细胞的蛋白质的外泌体。该模型的模拟显示了如何通过测量特定的miRs（在胰腺癌的情况下是miR-21和miR-203）来确定胰腺癌的大小，这表明这些miRs是癌症的生物标志物。
Exosomes are nanovesicles shed by cells as a means of communication with other cells. Exosomes contain mRNAs, microRNAs (miRs) and functional proteins. In the present paper, we develop a mathematical model of tumor-immune interaction by means of exosomes shed by pancreatic cancer cells and dendritic cells. Cancer cells' exosomes contain miRs that promote their proliferation and that inhibit immune response by dendritic cells, and by CD4+ and CD8+ T cells. Dendritic cells release exosomes with proteins that induce apoptosis of cancer cells and that block regulatory T cells. Simulations of the model show how the size of the pancreatic cancer can be determined by measurement of specific miRs (miR-21 and miR-203 in the case of pancreatic cancer), suggesting these miRs as biomarkers for cancer.