Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis.
Emerging Roles of the MICOS Complex in Cristae Dynamics and Biogenesis.
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DOI：
10.3390/biology10070600
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发表时间：
2021-06-29
期刊：
影响因子：
4.2
通讯作者：
Kondadi AK
中科院分区：
文献类型：
--
作者：
Anand R;Reichert AS;Kondadi AK
线粒体具有外膜和内膜。内膜与外膜平行的部分称为内边界膜，而嵴膜向线粒体基质折叠并容纳呼吸链复合物。嵴连接位于内边界膜和嵴膜的界面处，包含重要的“线粒体接触位点和嵴组织系统”复合体。尽管越来越多的证据表明线粒体内膜可以重塑，但近七十年来，嵴膜在很大程度上被认为是静态的，因为观察结果主要基于电子显微镜和断层扫描。最近，利用荧光超分辨率技术，多项研究表明嵴膜在活细胞中经历动态重塑，甚至可能发生内膜的裂变和融合。在这篇综述中，我们讨论了最近的重要文献，这些文献传达了 MICOS 复合体在嵴动力学中的新兴作用及其与嵴生物发生的关系。由于异常的内膜结构与心肌病、神经退行性变和糖尿病等各种病理有关，了解与嵴生物发生和动力学相关的各种分子的作用将有助于阐明病理生理学，并可能在不久的将来带来治疗方法。线粒体是双层膜封闭的细胞器，执行重要的细胞和代谢功能，例如 ATP 生成、血红素生物发生、细胞凋亡、ROS 产生和钙缓冲。使用包括“线粒体接触位点和嵴组织系统”(MICOS) 复合体、动力样 GTPase OPA1、F1FO ATP 合酶和心磷脂在内的分子因子，将线粒体内膜 (IM) 折叠成各种形状的嵴膜 (CM)。异常的嵴结构与不同的疾病有关，例如糖尿病、神经退行性变、癌症和肝性脑病。在这篇综述中，我们通过关注 MICOS 复合体在嵴动力学和嵴塑造中的新作用，提供了关于嵴生物发生的最新观点。七十多年来，嵴被认为是静态结构。最近的研究表明，嵴不断经历快速的动态重塑事件。几项研究重新调整了我们对线粒体区室动态内部氛围的看法。此外，我们还讨论了最近的文献，这些文献揭示了嵴生物发生方面仍知之甚少的方面，重点关注 MICOS 及其亚基的作用。总的来说，我们对嵴的生物发生和嵴动力学的新方面之间的关系提供了一个综合和更新的观点。
Mitochondria possess an outer and inner membrane. The part of the inner membrane parallel to the outer membrane is termed the inner boundary membrane, while the cristae membrane folds towards the mitochondrial matrix and houses the respiratory chain complexes. Crista junctions are located at the interface of the inner boundary membrane and the cristae membrane and contain the important ‘mitochondrial contact site and cristae organizing system’ complex. Despite the growing evidence that the mitochondrial inner membrane could remodel, cristae membranes were largely considered static for nearly seventy years, as the observations were mostly based on electron microscopy and tomography. Recently, using fluorescence super-resolution techniques, several studies showed that cristae membranes undergo dynamic remodeling in living cells, and probably even fission and fusion of the inner membrane. In this review, we discuss the important recent literature conveying the emerging role of the MICOS complex in cristae dynamics and its relation to cristae biogenesis. As the aberrant inner membrane architecture is connected to various pathologies such as cardiomyopathies, neurodegeneration and diabetes, understanding the roles of various molecules connected with cristae biogenesis and dynamics would shed light on the pathophysiology, probably leading to therapeutics in the near future. Mitochondria are double membrane-enclosed organelles performing important cellular and metabolic functions such as ATP generation, heme biogenesis, apoptosis, ROS production and calcium buffering. The mitochondrial inner membrane (IM) is folded into cristae membranes (CMs) of variable shapes using molecular players including the ‘mitochondrial contact site and cristae organizing system’ (MICOS) complex, the dynamin-like GTPase OPA1, the F1FO ATP synthase and cardiolipin. Aberrant cristae structures are associated with different disorders such as diabetes, neurodegeneration, cancer and hepato-encephalopathy. In this review, we provide an updated view on cristae biogenesis by focusing on novel roles of the MICOS complex in cristae dynamics and shaping of cristae. For over seven decades, cristae were considered as static structures. It was recently shown that cristae constantly undergo rapid dynamic remodeling events. Several studies have re-oriented our perception on the dynamic internal ambience of mitochondrial compartments. In addition, we discuss the recent literature which sheds light on the still poorly understood aspect of cristae biogenesis, focusing on the role of MICOS and its subunits. Overall, we provide an integrated and updated view on the relation between the biogenesis of cristae and the novel aspect of cristae dynamics.
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影响因子：
11.1
作者：
Genin EC;Plutino M;Bannwarth S;Villa E;Cisneros-Barroso E;Roy M;Ortega-Vila B;Fragaki K;Lespinasse F;Pinero-Martos E;Augé G;Moore D;Burté F;Lacas-Gervais S;Kageyama Y;Itoh K;Yu-Wai-Man P;Sesaki H;Ricci JE;Vives-Bauza C;Paquis-Flucklinger V
通讯作者：
Paquis-Flucklinger V
影响因子：
16.8
作者：
Drin, Guillaume;Casella, Jean-Francois;Antonny, Bruno
通讯作者：
Antonny, Bruno
ChChd3 是一种线粒体内膜蛋白，对于维持嵴完整性和线粒体功能至关重要。
DOI：
10.1074/jbc.m110.171975
发表时间：
2011-01-28
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Darshi M;Mendiola VL;Mackey MR;Murphy AN;Koller A;Perkins GA;Ellisman MH;Taylor SS
通讯作者：
Taylor SS
影响因子：
4
作者：
Beninca, Cristiane;Zanette, Vanessa;Zeviani, Massimo
通讯作者：
Zeviani, Massimo
影响因子：
4.8
作者：
Bustos, DM;Velours, J
通讯作者：
Velours, J