The Evaluation of Hepatic Fibrosis Scores in Children with Nonalcoholic Fatty Liver Disease
The Evaluation of Hepatic Fibrosis Scores in Children with Nonalcoholic Fatty Liver Disease
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DOI：
10.1007/s10620-014-3494-7
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发表时间：
2015-05-01
影响因子：
3.1
通讯作者：
Alkhouri, Naim
中科院分区：
文献类型：
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作者：
Mansoor, Sana;Yerian, Lisa;Alkhouri, Naim
背景 非酒精性脂肪肝病 (NAFLD) 是儿童慢性肝病最常见的形式，在儿童期可进展为肝硬化。活检中纤维化程度较高的患者往往会出现更多的肝脏并发症。已经为成年 NAFLD 患者制定了无创性肝纤维化评分；然而，这些分数尚未在儿童中得到验证。我们研究的目的是评估其中一些分数，以评估活检证实的 NAFLD 儿童是否存在纤维化。方法我们的研究包括来自美国五个主要中心的 92 名活检证实的 NAFLD 儿童。纤维化由经验丰富的病理学家确定（F0-4）。临床上显着的纤维化定义为纤维化阶段≥2，晚期纤维化定义为F3-4。计算每个儿童的以下纤维化评分：AST/ALT 比值、AST/血小板比值指数 (APRI)、NAFLD 纤维化评分 (NFS) 和 FIB-4 指数。进行 ROC 是为了评估不同评分的性能，以预测任何、显着或晚期纤维化的存在。 p值
Background Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in children and can progress to liver cirrhosis during childhood. Patients with more advanced fibrosis on biopsy tend to have more liver complications. Noninvasive hepatic fibrosis scores have been developed for adult patients with NAFLD; however, these scores have not been validated in children. The aim of our study was to evaluate some of these scores in assessing the presence of fibrosis in children with biopsy-proven NAFLD.Methods Our study consisted of 92 biopsy-proven NAFLD children from five major US centers. Fibrosis was determined by an experienced pathologist (F0-4). Clinically significant fibrosis was defined as fibrosis stage >= 2, and advanced fibrosis was defined as F3-4. The following fibrosis scores were calculated for each child: AST/ALT ratio, AST/platelet ratio index (APRI), NAFLD fibrosis score (NFS), and FIB-4 index. ROC was performed to assess the performance of different scores for prediction of presence of any, significant, or advanced fibrosis. A p value