Salivary alpha amylase as marker for adrenergic activity during stress: Effect of betablockade
Salivary alpha amylase as marker for adrenergic activity during stress: Effect of betablockade
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DOI：
10.1016/j.psyneuen.2005.05.012
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发表时间：
2006-01-01
影响因子：
3.7
通讯作者：
Wolf, OT
中科院分区：
文献类型：
--
作者：
van Stegeren, A;Rohleder, N;Wolf, OT
游离唾液皮质醇是一种确定的下丘脑-垂体-肾上腺（HPA）轴活性的非侵入性标志物。相比之下，这种表征良好的交感-肾上腺髓质（SAM）系统活性的唾液标志物仍然缺失。唾液α淀粉酶（sAA）是一种潜在的候选酶。在人类中，sAA水平的增加被观察到是对生理和心理压力的反应。本研究旨在探讨药理学操作（β阻断）对sAA在应激性fMRI情绪信息处理实验背景下的影响。30名年轻健康受试者参加了双盲组比较研究，并接受80毫克β受体阻滞剂（BB）心得安。或安慰剂（PL）。分别于给药前、扫描前90 min和扫描后135 min采集唾液样本。此外，还评估了心率和血压。在休息期间，观察到明显的药物时间相互作用，降低了β受体阻滞剂治疗组的sAA水平以及心率和收缩压。在扫描过程中，当参与者面对高度消极的情绪图片时，与BB组相比，PL组的sAA水平显著增加。在扫描期间，在PL组或BB组没有发现心率或血压的额外变化。目前的人体药理学研究为sAA对肾上腺素能激活变化的敏感性，特别是对心理应激的反应提供了直接证据。(c) 2005 Elsevier Ltd版权所有。
Free salivary cortisol is an established non-invasive marker of hypothalamus pituitary adrenal (HPA) axis activity. In contrast, such a wellcharacterized salivary marker for activity of the sympatho-adrenal medular (SAM) system is still missing. As one potential candidate salivary alpha amylase (sAA) has been suggested. In humans increases in sAA levels have been observed in response to physiological and psychological stress. The present study aimed at exploring the effects of a pharmacological manipulation (betablockade) on sAA in the context of a stressful fMRI experiment on emotional information processing. Thirty young healthy subjects participated in a double blind group comparison study and received 80 mg of the betablocker (BB) propranolol. or a placebo (PL). Salivary samples were obtained before and 90 min (pre-scan) and 135 min (post-scan) after drug application. In addition heart rate and blood pressure were assessed. During rest a significant drug by time interaction was observed, lowering sAA levels as well as heart rate and systolic blood pressure in the betablocker treatment group. During the scanning procedure, in which participants were confronted with highly negative emotional pictures, the significant increase in sAA levels in the PL group compared to the BB group persisted. No additional change was noticed in heart rate or blood pressure during scanning in the PL or BB group. The current pharmacological study in the human provides direct evidence for the sensitivity of sAA to changes in adrenergic activation, specifically in reaction to psychological stress. (c) 2005 Elsevier Ltd. All rights reserved.