Three-Fluid Sequential Micromixing-Assisted Nanoparticle Synthesis Utilizing Alternating Current Electrothermal Flow
Three-Fluid Sequential Micromixing-Assisted Nanoparticle Synthesis Utilizing Alternating Current Electrothermal Flow
复制标题
利用交流电热流的三流体顺序微混合辅助纳米颗粒合成
DOI：
10.1021/acs.iecr.0c02068
复制
发表时间：
2020-07-08
影响因子：
4.2
通讯作者：
Jiang, Hongyuan
中科院分区：
文献类型：
--
作者：
Sun, Haizhen;Ren, Yukun;Jiang, Hongyuan
在可控的顺序中进行多次微混合是复杂化学合成具有所需物理化学性质的功能纳米颗粒的必要过程。在此，我们开发了一个独特的利用交流电热流（ACET）的顺序微混合辅助纳米颗粒合成平台。首先设计了一种由一对交错不对称电极组成的双流体微混合器，并通过数值模拟和实验相结合的方法对其进行了表征，得到了直线通道内电极的优化配置。在此基础上，在主通道入口额外增加一对对称电极，形成三流体顺序微混合器。中间流体首先通过上游区域的对称ACET微涡对与侧流体混合，然后通过下游区域的非对称ACET微涡实现侧流体混合。在27.5 V和1 MHz的交流信号下，在相对高的流速下，观察到短通道中快速而完全的混合，流速可达7 mm/s。通过灵活调节三流体混合器内各流体的体积和交流电压，实现了连续微混合。采用两种流体混合工艺和三种流体混合工艺合成了钴铁普鲁士蓝模拟纳米颗粒。与两种流体混合相比，三种流体顺序混合提供了更高的分散性、颗粒形态可控和更规则的形状。因此，基于ACET流动的顺序微混合策略可以作为复杂化学和生化反应的替代方案。
Multiple micromixing in a controlled sequence is an essential process for complex chemical synthesis of functional nanoparticles with desired physicochemical properties. Herein, we developed a unique sequential micromixing-assisted nanoparticle synthesis platform utilizing alternating current electrothermal flow (ACET). A two-fluid micromixer comprised with pairs of staggered asymmetric electrodes was first designed and characterized by joint numerical simulations and experiments to obtain the optimized electrode configuration within a straight channel. On this basis, an extra pair of symmetric electrodes was added at the main channel entrance to form a three-fluid sequential micromixer. The middle fluid would first mix with the side fluids through the symmetric ACET microvortex pair in the upstream region and then realize the side fluid mixing by the asymmetric ACET microvortex in the downstream region. Rapid and complete mixing in a short channel was observed for a relatively high flow velocity up to 7 mm/s at an AC signal of 27.5 V and 1 MHz. Sequential micromixing was achieved by flexibly adjusting the volume of each fluid and the AC voltage within the three-fluid mixer. Both the two-fluid mixing process and the three-fluid mixing process were applied to synthesize the Co-Fe Prussian blue analogue nanoparticles. In comparison with two-fluid mixing, three-fluid sequential mixing offers nanoparticles with higher dispersion, controlled particle morphology, and more regular shapes. Therefore, the ACET flow-based sequential micromixing strategy can be an alternative for complex chemical and biochemical reactions.