Intracellular recordings from supporting cells in the guinea-pig cochlea: AC potentials.
Intracellular recordings from supporting cells in the guinea-pig cochlea: AC potentials.
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DOI：
10.1121/1.398092
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发表时间：
1989-09
期刊：
影响因子：
--
通讯作者：
E. Oesterle;P. Dallos
中科院分区：
文献类型：
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作者：
E. Oesterle;P. Dallos
采用细胞内记录和辣根过氧化物酶标记技术对豚鼠耳蜗低频区支持细胞和毛细胞进行了体内研究。将支持细胞对不同声级、频率和持续时间的音调爆发的反应特征与毛细胞在Corti液腔器官中记录的反应和电位进行了比较。研究结果表明，支持细胞反应的基本组成部分来自毛细胞产生的电流。支持细胞反应的这一组成部分可能是由于受体电流通过非特化膜斑块穿过支持细胞膜，或穿过非特化膜并通过连接相邻支持细胞的间隙连接而产生的。研究结果表明毛细胞和邻近的支持细胞之间缺乏电紧耦合。
Supporting cells and hair cells from the low-frequency region of the guinea-pig cochlea were studied in vivo using intracellular recording and horseradish peroxidase marking techniques. Response characteristics of the support cells to tone bursts at various sound levels, frequencies, and durations were compared to hair-cell responses and potentials recorded in the organ of Corti fluid spaces. Findings suggest that the fundamental component of the support-cell response accrues from hair-cell-generated currents. This component of the support-cell response probably results from the flow of receptor currents across support-cell membranes through nonspecialized membrane patches, or across nonspecialized membranes and through gap junctions that couple adjacent support cells. Findings suggest a lack of electrotonic coupling between hair cells and neighboring support cells.