Influenza vaccine effectiveness in preventing hospitalizations and deaths in persons 65 years or older in Minnesota, New York, and Oregon: Data from 3 health plans
Influenza vaccine effectiveness in preventing hospitalizations and deaths in persons 65 years or older in Minnesota, New York, and Oregon: Data from 3 health plans
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DOI：
10.1086/323085
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发表时间：
2001-09-15
影响因子：
6.4
通讯作者：
Nichol, KL
中科院分区：
文献类型：
--
作者：
Nordin, J;Mullooly, J;Nichol, KL
这项研究开发了方法并确定了 3 个大型健康计划中流感疫苗接种对老年人的影响：Kaiser Permanente Northwest、HealthPartners 和 Oxford Health Plan。 1996-1997 和1997-1998 赛季的数据是从行政数据库中提取的。受试者是年龄大于或等于 65 岁的健康计划成员。前一年收集的合并症用于通过逻辑回归进行风险调整。第一年的病毒与疫苗匹配非常好，第二年则相当。这两年，在高峰期和总体时期，疫苗接种减少了肺炎和流感的所有死亡原因和住院治疗：第一年和第二年的住院治疗分别减少了 19%-20% 和 18%-24%，同期死亡人数减少了 60%-61% 和 35%-39%。这些结果表明，所有老年人都应每年接种流感疫苗。本研究中使用的方法是研究疫苗影响和类似问题的有效且经济有效的方法。
This study developed methods and determined the impact of influenza vaccination on elderly persons in 3 large health plans: Kaiser Permanente Northwest, HealthPartners, and Oxford Health Plans. Data for the 1996-1997 and 1997-1998 seasons were extracted from administrative databases. Subjects were health plan members greater than or equal to 65 years old. Comorbid conditions collected from the preceding year were used for risk adjustment with logistic regression. The virus-vaccine match was excellent for year 1 and fair for year 2. Both years, during peak and total periods, vaccination reduced all causes of death and hospitalization for pneumonia and influenza: hospitalizations were reduced by 19%-20% and 18%-24% for years 1 and 2, respectively, and deaths were reduced by 60%-61% and 35%-39% for the same periods. These results show that all elderly persons should be immunized annually for influenza. The methods used in this study are an efficient cost-effective way to study vaccine impact and similar questions.