Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.
Trajectory Analysis of Cognitive Outcomes in Children With Perinatal HIV.
复制标题
围产期艾滋病毒儿童认知结果的轨迹分析。
DOI：
10.1097/inf.0000000000002427
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Saphonn,Vontha
中科院分区：
文献类型：
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作者：
Patel,PayalB;Apornpong,Tanakorn;Puthanakit,Thanyawee;Thongpibul,Kulvadee;Kosalaraksa,Pope;Hansudewechakul,Rawiwan;Kanjanavanit,Suparat;Ngampiyaskul,Chiawat;Luesomboon,Wicharn;Wongsawat,Jurai;Sun,LyPenh;Chettra,Kea;Saphonn,Vontha
Background:Children with perinatal HIV (pHIV) may display distinct long-term cognitive phenotypes. We used group-based trajectory modeling to identify clusters of children with pHIV after similar developmental trajectories and predictors of belonging to select cognitive trajectory groups.Methods:Participants included children, 4–17 years of age, with pHIV in Thailand and Cambodia. Cognitive measures included translated versions of Intelligence Quotient tests, Color Trails Tests and Beery-Buktenica Developmental Test of Visual-Motor Integration conducted semiannually over 3–6 years. The best fit of trajectory groups was determined using maximum likelihood estimation. Multivariate logistic regression identified baseline factors associated with belonging to the lowest scoring trajectory group.Results:Group-based trajectory analyses revealed a 3-cluster classification for each cognitive test, labeled as high, medium and low scoring groups. Most trajectory group scores remained stable across age. Verbal IQ declined in all 3 trajectory groups and the high scoring group for Children’s Color Trails Test 1 and 2 showed an increase in scores across age. Children in the lowest scoring trajectory group were more likely to present at an older age and report lower household income.Conclusions:
