DNAS OF THE 2 MATING-TYPE ALLELES OF NEUROSPORA-CRASSA ARE HIGHLY DISSIMILAR
DNAS OF THE 2 MATING-TYPE ALLELES OF NEUROSPORA-CRASSA ARE HIGHLY DISSIMILAR
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DOI：
10.1126/science.2840740
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发表时间：
1988-07-29
期刊：
影响因子：
56.9
通讯作者：
YANOFSKY, C
中科院分区：
文献类型：
--
作者：
GLASS, NL;VOLLMER, SJ;YANOFSKY, C
交配型等位基因A和α。在有性周期中控制交配，在营养周期中起到建立异核体不亲和性的作用。克隆了A和a等位基因，它们既编码有性功能，又编码营养不亲和性。交配型克隆包含非同源的DNA片段，两侧是共同的DNA序列。粗糙脉孢菌和所有异种和假同种脉孢子菌在每个单倍体基因组中都含有一种交配型序列或另一种交配型序列的单一副本。已知的六个自育同系分离物包含A同源基因，但只有一个物种也包含同源序列。这些物种的同皮化不是由于交配类型的转换，而是由于酿酒酵母的。
The mating-type alleles A and .alpha. of Neurospora crassa control mating in the sexual cycle and function in establishing heterokaryon incompatibility in the vegetative cycle. The A and a alleles were cloned, and they were shown to encode both the sexual functions and vegetative incompatibility. The mating-type clones contain nonhomologous DNA segments that are flanked by common DNA sequences. Neurospora crassa and all heterothallic and pseudohomothallic Neurospora species contain a single copy of one mating-type sequence or the other within each haploid genome. The six known self-fertile homothallic isolates contain an A homolog, but only one species also contains a homologous sequence. Homothallism in these species is not due to mating-type switching, as it is in Saccharomyces cerevisiae.