Survey of GMP bulk reactions run in a research facility between 1985 and 2002
Survey of GMP bulk reactions run in a research facility between 1985 and 2002
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DOI：
10.1021/op050021j
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发表时间：
2005-05-01
影响因子：
3.4
通讯作者：
Ripin, DHB
中科院分区：
文献类型：
--
作者：
Dugger, RW;Ragan, JA;Ripin, DHB
对Pfizer-Groton工厂GMP设施中的反应规模进行了审查。反应分为七类之一：碳-碳键形成，羧酸衍生物相互转化，碳-氮键形成，碳-氧键形成，red-ox，盐形成/拆分等。将1997年至2002年的反应与1985年至1996年的化学反应进行了比较，以寻找两个时间段之间化学性质的变化。在这些类别中对反应作了进一步的细分，并注意到一些有趣的趋势。
A review of reactions scaled in the GMP facilities at the Pfizer-Groton site was undertaken. Reactions were categorized into one of seven categories: carbon-carbon bond formation, carboxylic acid derivative interconversion, carbon-nitrogen bond formation, carbon-oxygen bond formation, red-ox, salt formation/resolution, and other. Reactions scaled from 1997 to 2002 were compared to chemistry scaled from 1985 to 1996 to look for changes in the nature of chemistry being scaled between the two time periods. Reactions were further subcategorized within those categories, and some interesting trends were noted.