Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype
Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype
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DOI：
10.1016/j.bmcl.2009.09.105
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发表时间：
2009-11-15
影响因子：
2.7
通讯作者：
Cabrele, Chiara
中科院分区：
文献类型：
--
作者：
Pellegrino, Sara;Ferri, Nicola;Cabrele, Chiara
在血管损伤形成后观察到平滑肌细胞向增殖和迁移表型的调节，其中α-肌动蛋白表达下调。Id蛋白（细胞分化抑制剂）在这种表型的发展中发挥作用。相比之下，基于保守的11个残基Id序列的合成肽触发向收缩表型的转换，其显示细胞生长和迁移减少、α-肌动蛋白表达增加和Id蛋白水平降低。(C)2009爱思唯尔有限公司保留所有权利。
Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated alpha-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of alpha-actin and decreased Id protein levels. (C) 2009 Elsevier Ltd. All rights reserved.