Oxygenated and reoxygenated tumors show better local control in radiation therapy for cervical cancer
Oxygenated and reoxygenated tumors show better local control in radiation therapy for cervical cancer
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DOI：
10.1111/j.1525-1438.2006.00341.x
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发表时间：
2006-01-01
影响因子：
4.8
通讯作者：
Tsujii, H
中科院分区：
文献类型：
--
作者：
Suzuki, Y;Nakano, T;Tsujii, H
缺氧细胞的存在是影响放射治疗抵抗力的主要因素之一。在临床上，关于肿瘤内氧分压（pO（2））和预后之间关系的信息很少。本研究涉及30例连续的宫颈癌患者，他们接受了外照射和高剂量率腔内照射的联合治疗。在放射治疗前和9戈伊时，使用针型极谱氧电极测量pO（2）。放射治疗前平均肿瘤内pO（2）为17.3 ± 10.8 mm Hg。放疗前pO（2）20 mm Hg的患者3年局部控制率分别为52%和100%，有显著差异（P = 0.035）。在9戈伊剂量下，平均肿瘤内pO（2）为23.6 +/- 9.1 mm Hg，与放射治疗前的值相比显著增加（P = 0.006）。9戈伊时pO（2）20 mm Hg的肿瘤的3年局部控制率分别为35%和93%，代表显著差异（P = 0.001）。放疗前及放疗后9戈伊的局部控制率均明显高于放疗前，表明放疗的氧效应和复氧作用在宫颈癌放疗的局部控制中起重要作用。
The presence of hypoxic cells is one of the major factors affecting resistance against radiation therapy. In the clinical setting, little information exists as to the relationship between intratumoral oxygen partial pressure (pO(2)) and outcome. This study involved 30 consecutive patients with cervical cancer, who were treated with a combination of external and high-dose rate intracavitary irradiation. The pO(2) was measured before radiation therapy and at 9 Gy, using a needle-type polarographic oxygen electrode. The mean intratumoral pO(2) before radiation therapy was 17.3 +/- 10.8 mm Hg. The 3-year local control rates of patients with pO(2) 20 mm Hg before radiation therapy were 52% and 100%, respectively, representing a significant difference (P = 0.035). At 9 Gy, mean intratumoral pO(2) was 23.6 +/- 9.1 mm Hg, a significant increase compared to the value before radiation therapy (P = 0.006). The 3-year local control rates of tumors with pO(2) 20 mm Hg at 9 Gy were 35% and 93%, respectively, representing a significant difference (P = 0.001). The significantly better local control for oxygenated tumors at 9 Gy as well as before radiation therapy indicated that the oxygen effect and reoxygenation by radiation played an important role in local control in radiation therapy for cervical cancer.