Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study.
Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study.
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DOI：
10.3389/fpsyt.2016.00111
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发表时间：
2016
影响因子：
4.7
通讯作者：
Hampson M
中科院分区：
文献类型：
--
作者：
Gerin MI;Fichtenholtz H;Roy A;Walsh CJ;Krystal JH;Southwick S;Hampson M
许多患有创伤后应激障碍（PTSD）的患者，尤其是退伍军人，对现有的治疗没有反应。在这里，我们描述了一种使用实时功能磁共振成像来治疗和研究 PTSD 的新型神经反馈 (NF) 干预措施。干预措施包括训练参与者在接触个性化创伤脚本后控制杏仁核活动。三名患有慢性创伤后应激障碍的退伍军人参加了这项可行性研究。所有三名参与者都很好地耐受了 NF 训练。此外，两名参与者尽管症状长期存在，但仍表现出具有临床意义的改善，而一名参与者的症状减轻幅度较小。对静息状态功能连接模式变化的检查表明，大脑连接正常化，与临床改善一致。这些初步结果支持了这种针对创伤后应激障碍（PTSD）的新型干预措施的可行性，并表明有必要进行更大规模、对照良好的疗效研究。
Many patients with post-traumatic stress disorder (PTSD), especially war veterans, do not respond to available treatments. Here, we describe a novel neurofeedback (NF) intervention using real-time functional magnetic resonance imaging for treating and studying PTSD. The intervention involves training participants to control amygdala activity after exposure to personalized trauma scripts. Three combat veterans with chronic PTSD participated in this feasibility study. All three participants tolerated well the NF training. Moreover, two participants, despite the chronicity of their symptoms, showed clinically meaningful improvements, while one participant showed a smaller symptom reduction. Examination of changes in resting-state functional connectivity patterns revealed a normalization of brain connectivity consistent with clinical improvement. These preliminary results support feasibility of this novel intervention for PTSD and indicate that larger, well-controlled studies of efficacy are warranted.