Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype
Reduced cholinergic function in normal and Alzheimer's disease brain is associated with apolipoprotein E4 genotype
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DOI：
10.1016/s0304-3940(97)00872-0
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发表时间：
1997-12-12
影响因子：
2.5
通讯作者：
Dawbarn, D
中科院分区：
文献类型：
--
作者：
Allen, SJ;MacGowan, SH;Dawbarn, D
载脂蛋白E(ApoE)是阿尔茨海默病的潜在危险因素。由于已知阿尔茨海默病的胆碱能功能丧失发生在疾病的早期阶段，我们检查了具有Apo epsilon 4等位基因的正常受试者的胆碱能功能，以了解在没有阿尔茨海默病病理或症状的情况下是否会发生这种功能缺陷。我们报告了从正常人和携带Apo epsilon 4等位基因的阿尔茨海默病患者死后获得的脑组织比没有该等位基因的受试者的脑组织胆碱能活性更低。这对于解释阿尔茨海默病中发现的胆碱能缺陷具有重要意义。(C)1997年爱思唯尔爱尔兰科学有限公司。
Apolipoprotein E (ApoE) is a potent risk factor for Alzheimer's disease. Since the loss of cholinergic function in Alzheimer's disease is known to occur at an early stage in the disease we have examined this function in normal subjects with an Apo epsilon 4 allele to see if the deficit occurs in the absence of Alzheimer pathology or symptoms. We report that brain tissue obtained post-mortem from normal subjects and Alzheimer patients with an Apo epsilon 4 allele has a lower cholinergic activity than tissue from those subjects without this allele. This has important significance for the interpretation of the cholinergic deficits found in Alzheimer's disease. (C) 1997 Elsevier Science Ireland Ltd.