Genomics and Pharmacogenomics of Salt-sensitive Hypertension
Genomics and Pharmacogenomics of Salt-sensitive Hypertension
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DOI：
10.2174/1573402111999150521102331
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发表时间：
2015-01-01
影响因子：
2.3
通讯作者：
Jose, Pedro A.
中科院分区：
文献类型：
--
作者：
Armando, Ines;Villar, Van Anthony M.;Jose, Pedro A.
盐敏感性估计存在于51%的高血压人群和26%的血压正常人群中。个体血压对盐的反应是异质的，可能与遗传易感性有关。虽然盐敏感性的机制很复杂，而且还不清楚，但遗传学可以帮助确定血液对盐摄入的反应。到目前为止，只有少数基因被发现与盐敏感性高血压相关的候选基因关联研究。肾脏对整体液体和电解质平衡以及血压的长期调节至关重要。因此，盐敏感性的发病机制必须涉及肾脏NaCl处理的紊乱：在NaCl负荷增加的情况下，不能减少肾脏钠转运和增加钠排泄，这可能是由异常的反调节利钠/抗心房利尿通路引起的。我们在此回顾了与盐敏感性高血压相关的基因变异以及这些基因变异的存在如何影响降压治疗反应的文献。
Salt sensitivity is estimated to be present in 51% of the hypertensive and 26% of the normotensive populations. The individual blood pressure response to salt is heterogeneous and possibly related to inherited susceptibility. Although the mechanisms underlying salt sensitivity are complex and not well understood, genetics can help to determine the blood response to salt intake. So far only a few genes have been found to be associated with salt-sensitive hypertension using candidate gene association studies. The kidney is critical to overall fluid and electrolyte balance and long-term regulation of blood pressure. Thus, the pathogenesis of salt sensitivity must involve a derangement in renal NaCl handling: an inability to decrease renal sodium transport and increase sodium excretion in the face of an increase in NaCl load that could be caused by aberrant counter-regulatory natriuretic/antinatriuretic pathways. We review here the literature regarding the gene variants associated with salt-sensitive hypertension and how the presence of these gene variants influences the response to antihypertensive therapy.