Pulmonary and pleural thymoma. Diagnostic application of lymphocyte markers to the thymoma of unusual site.
Pulmonary and pleural thymoma. Diagnostic application of lymphocyte markers to the thymoma of unusual site.
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DOI：
10.1093/ajcp/89.5.617
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发表时间：
1988-05
影响因子：
3.5
通讯作者：
Masashi Fukayama;Y. Maeda;N. Funata;Morio Koike;Ken Saito;T. Sakai;T. Ikeda
中科院分区：
文献类型：
--
作者：
Masashi Fukayama;Y. Maeda;N. Funata;Morio Koike;Ken Saito;T. Sakai;T. Ikeda
本文报告两例少见部位胸腺瘤的免疫组化检查结果。一个是肺内肿瘤，另一个是弥漫性胸膜肿瘤。肺内肿瘤浸润的淋巴细胞为OKT 6阳性和末端脱氧核苷酸转移酶（TdT）核免疫反应性的T细胞，与纵隔胸腺瘤中以淋巴细胞型或混合型为主的淋巴细胞相似。胸膜肿瘤中虽有散在分布的淋巴细胞，但也有少量TdT（+）OKT 6（-）淋巴细胞，胸腺瘤中也有类似的发现。在肺癌和胸膜间皮瘤中，TdT（+）OKT 6（+/-）淋巴细胞均未检出。淋巴细胞标记物的免疫组化研究可能是一个有用的工具，以诊断胸腺瘤的异位部位或不寻常的介绍。
Two cases of the thymoma of the unusual sites were examined immunohistochemically. The one was intrapulmonary, and the other was diffuse pleural tumors. The infiltrating lymphocytes were T-cells showing OKT 6 positivity and nuclear immunoreactivity for terminal deoxynucleotidyl transferase (TdT) in the intrapulmonary tumor, like lymphocytes in the mediastinal thymoma of predominantly lymphocytic or mixed types. Although lymphocytes were dispersed in the pleural tumor, there were some TdT(+) OKT 6(-) lymphocytes and the similar finding was observed in the thymoma of predominantly epithelial type. In lung carcinomas and pleural mesotheliomas, there were no TdT(+) OKT 6(+/-) lymphocytes. Immunohistochemical studies using lymphocyte markers may be an useful tool for the diagnosis of the thymoma of ectopic site or unusual presentation.