A mouse plasma peptide atlas as a resource for disease proteomics
A mouse plasma peptide atlas as a resource for disease proteomics
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DOI：
10.1186/gb-2008-9-6-r93
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发表时间：
2008-01-01
期刊：
影响因子：
12.3
通讯作者：
Hanash, Samir M.
中科院分区：
文献类型：
--
作者：
Zhang, Qing;Menon, Rajasree;Hanash, Samir M.
我们提出了一个深入的分析小鼠血浆导致发展的一个公开可用的存储库组成的568液相色谱-串联质谱运行。总共鉴定了13，779种不同的肽，具有很高的置信度。估计相应的约3，000种蛋白质在血浆中跨越7个对数范围的丰度。这项研究的一个主要发现是鉴定了以前从基因组分析中没有预测到的新亚型和转录变体。
We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have been identified with high confidence. The corresponding approximately 3,000 proteins are estimated to span a 7 logarithmic range of abundance in plasma. A major finding from this study is the identification of novel isoforms and transcript variants not previously predicted from genome analysis.