FDG uptake, tumour characteristics and response to therapy: A review
FDG uptake, tumour characteristics and response to therapy: A review
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DOI：
10.1097/00006231-199802000-00002
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发表时间：
1998-02-01
影响因子：
1.5
通讯作者：
Smith, TAD
中科院分区：
文献类型：
--
作者：
Smith, TAD
FDG-PET成像在肿瘤检测中的应用现在已经得到了很好的建立。许多研究表明，FDG摄取的变化可预测肿瘤对治疗的反应，并且关于肿瘤分级和增殖状态的进一步临床信息也可来自FDG摄取扫描。需要更多的研究来验证FDG-PET在患者管理中的作用。己糖激酶和葡萄糖转运蛋白，特别是Glut-1的上调，以及葡萄糖-6-磷酸酶的下调通常与转化相关。这些变化的程度与分化和增殖有关，主要与FDG摄取研究相对应。
The use of FDG-PET imaging in tumour detection is now well established. Many studies have suggested that changes in the uptake of FDG predict tumour response to therapy and that further clinical information regarding tumour grade and proliferative status may also be derived from FDG-uptake scans. More studies are required to verify the role of FDG-PET in patient management. Upregulation of hexokinase and glucose transporters, especially Glut-1, and downregulation of glucose-6-phosphatase are frequently associated with transformation. The extent of these changes has been related to both differentiation and proliferation largely corresponding with FDG-uptake studies.