T-cell recognition of self peptides as tumor rejection antigens
T-cell recognition of self peptides as tumor rejection antigens
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DOI：
10.1007/bf02918248
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发表时间：
1996-01-01
影响因子：
4.4
通讯作者：
Rosenberg, SA
中科院分区：
文献类型：
--
作者：
Kawakami, Y;Rosenberg, SA
人黑色素瘤抗原和T细胞识别的表位最近已被确定。黑色素瘤抗原MART-1和gp 100的HLA-A2结合表位的特点，并怀疑是次显性/隐蔽的自我决定簇。与肿瘤特异性突变自身肽作为T细胞识别的肿瘤抗原的其他发现一起，在分子水平上揭示了对人黑色素瘤的抗肿瘤免疫应答的性质。这些发现不仅对理解正常和病理条件下对自身肽的免疫应答具有意义，而且对癌症和自身免疫性疾病的免疫疗法的发展也具有意义。
Human melanoma antigens and their epitopes recognized by T cells have recently been identified. HLA-A2 binding epitopes of melanoma antigens MART-1 and gp100 were characterized and suspected to be subdominant/cryptic self determinants. Together with other findings of tumor-specific mutated self peptides as tumor antigens recognized by T cells, the nature of the antitumor immune response to human melanoma has been revealed at a molecular level. These findings have implications not only for understanding of the immune response to self peptides in normal and pathologic conditions, but also for the development of immunotherapies for cancer and autoimmune diseases.