Particulate matter and risk of Parkinson disease in a large prospective study of women.
Particulate matter and risk of Parkinson disease in a large prospective study of women.
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DOI：
10.1186/1476-069x-13-80
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发表时间：
2014-10-07
期刊：
影响因子：
--
通讯作者：
Laden F
中科院分区：
文献类型：
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作者：
Palacios N;Fitzgerald KC;Hart JE;Weisskopf MG;Schwarzschild MA;Ascherio A;Laden F
暴露于空气污染与许多不利的健康结果有关，颗粒物（PM）对大脑的影响正开始得到认识。然而，尚无前瞻性研究考察PM与帕金森病风险之间的关系。因此，我们的目标是在护士健康研究（NHS）中评估暴露于颗粒物空气污染是否与帕金森病（PD）的风险有关，这是一个大型前瞻性女性队列。在PD发病前2年，累积平均暴露于不同大小的PM组分，通过将每个人的居住地与特定地点的空气污染水平联系起来，使用时空模型进行估计。我们对115,767名NHS女性进行了前瞻性随访，确定了508例PD病例，并使用多变量Cox比例风险模型独立估计与PM各大小部分相关的PD风险。在调整了年龄（以月为单位）、吸烟、地区、人口密度、咖啡因和布洛芬摄入量的模型中，我们观察到空气污染暴露与PD风险之间没有统计学上显著的关联。PM10（直径≤10微米）暴露的最高四分位数与最低四分位数的相对危险度（RR）为0.99(95%可信区间（CI）： 0.84,1.16), PM2.5（直径≤2.5微米）暴露的相对危险度（RR）为1.08 (95% CI: 0.81, 1.45), PM10 - 2.5（直径≤2.5微米）暴露的相对危险度（RR）为0.92 （95% CI: 0.71, 1.19）。在这项研究中，我们没有发现暴露于空气污染是PD的危险因素的证据。
Exposure to air pollution has been implicated in a number of adverse health outcomes and the effect of particulate matter (PM) on the brain is beginning to be recognized. Yet, no prospective study has examined the association between PM and risk of Parkinson Disease. Thus, our goal was assess if exposure to particulate matter air pollution is related to risk of Parkinson’s disease (PD) in the Nurses’ Health Study (NHS), a large prospective cohort of women. Cumulative average exposure to different size fractions of PM up to 2 years before the onset of PD, was estimated using a spatio-temporal model by linking each individual’s places of residence throughout the study with location-specific air pollution levels. We prospectively followed 115,767 women in the NHS, identified 508 incident PD cases and used multivariable Cox proportional hazards models to estimate the risk of PD associated with each size fraction of PM independently. In models adjusted for age in months, smoking, region, population density, caffeine and ibuprofen intake, we observed no statistically significant associations between exposure to air pollution and PD risk. The relative risk (RR) comparing the top quartile to the bottom quartile of PM exposure was 0.99 (95% Confidence Intervals (CI): 0.84,1.16) for PM10 (≤10 microns in diameter), 1.08 (95% CI: 0.81, 1.45) for PM2.5 (≤2.5 microns in diameter), and 0.92 (95% CI: 0.71, 1.19) for PM10–2.5 (2.5 to 10 microns in diameter). In this study, we found no evidence that exposure to air pollution is a risk factor for PD.