Neuropsychological impairment in patients with schizophrenia and evidence of hyponatremia and polydipsia.
Neuropsychological impairment in patients with schizophrenia and evidence of hyponatremia and polydipsia.
复制标题
精神分裂症患者的神经心理损伤以及低钠血症和烦渴的证据。
DOI：
10.1037/a0014481
复制
发表时间：
2009
期刊：
影响因子：
2.4
通讯作者：
Goldman,MorrisB
中科院分区：
文献类型：
--
作者：
Torres,IvanJ;Keedy,Sarah;Marlow-O'Connor,Megan;Beenken,Beth;Goldman,MorrisB
患有精神分裂症和水分失调的患者可能是具有明显病理生理异常和认知障碍易感性的患者的一个子集。具体来说，患有多饮和低钠血症的患者海马前部体积较小，这也与神经内分泌功能的各种损伤有关。为了确定水分失衡患者的异常是否会扩展到认知领域，本研究评估了三组精神分裂症患者的神经心理功能：多饮性低钠血症、多饮性正常钠血症和非多饮性正常钠血症。参与者接受认知测试，评估智力、注意力、学习/记忆（语言、非语言、情感）和面部识别。低钠血症患者表现出较差的整体神经心理功能，而多饮正常钠血症患者表现为其他两组之间。结果表明，精神分裂症伴多饮的患者，尤其是低钠血症患者，相对于无水分失衡的患者表现出明显的认知缺陷。这些患者的临床、神经内分泌和认知异常可能是由海马前部和相关的前额叶/边缘脑区病理引起的。（PsycINFO数据库记录(c) 2017 APA，版权所有）
Patients with schizophrenia and water imbalance may represent a subset of patients with distinct pathophysiological abnormalities and susceptibility to cognitive impairment. Specifically, patients with polydipsia and hyponatremia have been shown to have smaller anterior hippocampal volumes, which are also associated with various impairments in neuroendocrine function. To determine whether abnormalities in patients with water imbalance extend to the cognitive realm, the present study evaluated neuropsychological functioning in three groups of patients with schizophrenia: polydipsic hyponatremic, polydipsic normonatremic, and nonpolydipsic normonatremic. Participants were administered cognitive tests assessing intelligence, attention, learning/memory (verbal, nonverbal, emotional), and facial discrimination. Hyponatremic patients showed poorer overall neuropsychological functioning relative to all other patients, and polydipsic normonatremic patients performed intermediate to the other two groups. Results indicate that patients with schizophrenia and polydipsia, and particularly those with hyponatremia, show prominent cognitive deficits relative to patients without water imbalance. The clinical, neuroendocrine, and cognitive abnormalities in these patients may arise from pathology within the anterior hippocampus and associated prefrontal/limbic brain regions.(PsycINFO Database Record (c) 2017 APA, all rights reserved)