Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage
Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage
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厚朴酚治疗通过调节炎症和粘膜损伤减轻葡聚糖硫酸钠诱导的小鼠实验性结肠炎
DOI：
10.1016/j.lfs.2018.01.016
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发表时间：
2018-03-01
期刊：
影响因子：
6.1
通讯作者：
Cao, Yongguo
中科院分区：
文献类型：
--
作者：
Shen, Peng;Zhang, Zecai;Cao, Yongguo
厚朴酚是厚朴的主要有效成分，在传统方剂中被广泛应用于治疗人体疾病。厚朴酚具有抗菌、抗氧化、抗炎等药理活性。然而，厚朴酚对溃疡性结肠炎（UC）的影响尚未报道。本研究旨在探讨厚朴酚对葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎的保护作用及其机制。结果表明，厚朴酚能显著减轻DSS所致小鼠体重下降、疾病活动指数（DAI）、结肠长度缩短和结肠病理损伤。此外，厚朴酚通过调节核因子-κ B（NF-κ B）和过氧化物酶体增殖物激活受体-γ（PPAR-gamma）通路抑制TNF-α、IL-1 β和IL-12的表达。厚朴酚还可增强DSS诱导的小鼠结肠组织中ZO-1和occludin的表达。这些结果表明，厚朴酚对DSS诱导的结肠炎具有保护作用，可能是结肠炎治疗的替代治疗剂。
Magnolol, the main and active ingredient of the Magnolia officinalis, has been widely used in traditional prescription to the human disorders. Magnolol has been proved to have several pharmacological properties including anti-bacterial, anti-oxidant and anti-inflammatory activities. However, the effects of magnolol on ulcerative colitis (UC) have not been reported. The aim of this study was to investigate the protective effects and mechanisms of magnolol on dextran sulphate sodium (DSS)-induced colitis in mice. The results showed that magnolol significantly alleviated DSS-induced body weight loss, disease activities index (DAI), colon length shortening and colonic pathological damage. In addition, magnolol restrained the expression of TNF-alpha, IL-1 beta and IL-12 via the regulation of nuclear factor-kappa B (NF-kappa B) and Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) pathways. Magnolol also enhanced the expression of ZO-1 and occludin in DSS-induced mice colonic tissues. These results showed that magnolol played protective effects on DSS-induced colitis and may be an alternative therapeutic reagent for colitis treatment.