Obsessive-Compulsive Disorder and Its Potential Subtypes
Obsessive-Compulsive Disorder and Its Potential Subtypes
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DOI：
10.1017/s1092852900025037
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发表时间：
2000-06-01
期刊：
影响因子：
3.3
通讯作者：
Black, Donald W.
中科院分区：
文献类型：
--
作者：
Black, Donald W.
这份手稿总结了代表巴西、以色列、意大利、墨西哥、葡萄牙、西班牙和美国的国际专家小组在一个研讨会上关于强迫症(OCD)及其可能的亚型的陈述。报告既涉及强迫症本身，也涉及推定的强迫症谱系障碍(自闭症、进食障碍、病态赌博和精神分裂-强迫症)。讨论的项目包括一项评估进食障碍患者冲动气质的研究，一项关于血清素的研究。自闭症的感受器敏感性研究，睡眠脑电异常的研究，分裂病态赌徒的研究，分裂强迫症患者方面的研究，强迫症生物学改变的研究，强迫症的一项新的家庭研究数据，强迫症的分子遗传学研究数据，抽动障碍的因素分析研究，强迫症连续体存在的假设研究，以及最后，一篇关于早发性强迫症与迟发性强迫症的论文。随后的一般性讨论导致达成共识：1)强迫症可能是异质性的，有多个亚型；2)根据发病年龄对患者进行划分可能代表了一种稳健和有效的亚型方案；3)精神分裂症特征的存在可能确定了一个有效的亚型；4)未来亚型的确认将由家庭遗传学研究以及对生物变化的研究提供信息，例如强迫症；以及5)强迫症谱系障碍的研究增加了我们对强迫症现象的理解，并有助于我们寻找有效的亚型。CNS光谱2000；5(6)附录4：40-46
This manuscript summarizes presentations by an international panel of experts, representing Brazil, Israel, Italy, Mexico, Portugal, Spain, and the United States, at a symposium, on obsessive-compulsive disorder (OCD) and its possible subtypes. Presentations concerned both OCD proper, as well as putative obsessive-compulsive-spectrum disorders (autistic disorders, eating disorders, pathological gambling, and schizo-obsessive disorder). Projects discussed included a study assessing impulsive temperament in eating disorder patients, a study on serotonin. receptor sensitivity in autism, a study of sleep EEG abnormalities tit OCD, a study of dissociation tit pathological gamblers, papers on aspects of schizo-obsessive patients, a study addressing biological alterations lit OCD, data from a new family study on OCD, data from a molecular genetic study of OCD, a factor analytic study of Tourette disorder, a study hypothesizing the existence of an OCD continuum, and, finally, a paper on early- vs late-onset OCD. General discussion followed leading to a consensus that 1) OCD is likely heterogeneous with multiple subtypes; 2) division of patients by age-at-onset probably represents a robust and valid subtyping scheme; 3) the presence of schizophrenic features probably identifies a valid subtype; 4) the validation of subtypes in the future will be informed by both family-genetic studies, as well as studies of biological alterations tit OCD; and 5) the study of obsessive-compulsive spectrum disorders adds to our understanding of the OCD phenomenon, and helps in our search to identify valid subtypes. CNS Spectrums 2000;5(6)suppl 4:40-46