PTK7 as a novel marker for favorable gastric cancer patient survival
PTK7 as a novel marker for favorable gastric cancer patient survival
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PTK7 作为胃癌患者生存的新标志物
DOI：
10.1002/jso.23154
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发表时间：
2012-12-01
影响因子：
2.5
通讯作者：
Ji, Jia-Fu
中科院分区：
文献类型：
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作者：
Lin, Yi;Zhang, Lian-Hai;Ji, Jia-Fu
背景和目的：蛋白酪氨酸激酶 7 (PTK7) 在多种癌症类型中发挥重要作用，但其在胃癌中的表达仍不清楚。本研究旨在探讨PTK7在胃癌中的表达。方法：采用免疫组化法检测201例胃癌患者PTK7的表达。统计分析PTK7表达与临床病理特征和患者预后的关系。结果：56.72%的胃癌患者（201例中有114例）检测到PTK7表达。免疫染色主要位于细胞质中。统计分析显示，PTK7表达在高分化肿瘤患者中更常见（P = 0.001）。此外，PTK7 表达与良好的总生存期（OS；P = 0.012）和无病生存期（DFS；P = 0.009）显着相关。多变量 Cox 回归分析显示，PTK7 表达是良好 OS（P = 0.028）和 DFS（P = 0.012）的独立预后因素。结论：我们的研究结果表明，PTK7 可以作为胃癌患者的新型预后生物标志物。 J.外科医生。安科尔。 2012年； 106：880886。 (C) 2012 年 Wiley 期刊公司。
Background and Objectives: Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer.Methods: PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed.Results: PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012).Conclusion: Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients. J. Surg. Oncol. 2012; 106:880886. (C) 2012 Wiley Periodicals, Inc.