Bone mineral density evaluation of patients with type 2 diabetes mellitus
Bone mineral density evaluation of patients with type 2 diabetes mellitus
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DOI：
10.1589/jpts.27.179
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发表时间：
2015-01-01
影响因子：
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通讯作者：
Guler, Mustafa
中科院分区：
文献类型：
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作者：
Adil, Camli;Aydin, Teoman;Guler, Mustafa
[目的]糖尿病是由于胰岛素分泌、胰岛素作用或两者缺陷而引起的代谢紊乱。其结果是慢性高血糖症，伴随碳水化合物、脂肪和蛋白质代谢紊乱。我们调查了糖尿病患者和对照组在腰椎和股骨BMD（骨矿物质密度）和标准差评分（Z评分和T评分）方面是否有任何差异。[受试者和方法]这项随机、前瞻性、对照、单盲研究在Bezm-i Alem Vakif大学医学院物理医学和康复系进行。患者组包括2型糖尿病患者。健康人被纳入对照组。[结果]共126例患者完成研究，其中研究组63例，对照组63例。两组实验室检查结果差异无统计学意义。2型糖尿病组腰椎（L1-4）T评分的骨密度明显较低。[结论]骨质疏松是1型糖尿病的潜在并发症之一，但其对2型糖尿病患者骨密度的影响存在争议。在不同的研究中，骨密度值增加，减少或保持正常。除腰椎（L1-4）T评分外，本研究获得了相似的结果。
[Purpose] Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. A consequence of this is chronic hyperglycemia with disturbances in carbohydrate, fat and protein metabolism. We investigated whether there is any difference among DM patients and a control group in terms of lumbar and femur BMD (bone mineral density), and standard deviation scores (Z score and T score). [Subjects and Methods] This randomized, prospective, controlled, single-blind study was conducted in the Physical Medicine and Rehabilitation Department Faculty of Medicine, Bezm-i Alem Vakif University. Patients with type 2 diabetes mellitus were included in the patient groups. Healthy individuals were included in the control group. [Results] A total of 126 patients completed the study (63 in the study group, 63 in the control group). There was no significant difference in the results of the laboratory examinations of the cases. The bone mineral densities of the cases were found to be significantly low in terms of the lumbar (L1-4) T scores in the type 2 diabetes group. [Conclusion] Although osteoporosis is one of the potential complications of type 1 diabetes, its effect on bone mineral density in type 2 DM is controversial. In different studies, the bone mineral density values have increased, decreased or remained normal. With the exception of the lumbar (L1-4) T score, similar results were obtained in this study.