Persistent pruritic papules and plaques: a characteristic histopathologic presentation seen in a subset of patients with adult-onset and juvenile Still's disease
Persistent pruritic papules and plaques: a characteristic histopathologic presentation seen in a subset of patients with adult-onset and juvenile Still's disease
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DOI：
10.1111/j.1600-0560.2010.01570.x
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发表时间：
2010-09-01
影响因子：
1.7
通讯作者：
Patel, Rajiv M.
中科院分区：
文献类型：
--
作者：
Fortna, Ryan R.;Gudjonsson, Johann E.;Patel, Rajiv M.
背景：斯蒂尔病的“持续性瘙痒丘疹和斑块”是最近在部分患者中发现的一种皮疹。到目前为止，文献中报道的大多数病例都与成人发病的斯蒂尔病有关。方法：我们报告了3例女性患者的临床和组织病理学检查，年龄从15岁到54岁不等。结果：我们的3例患者的临床表现与斯蒂尔病一致。最年轻的患者患有幼年型斯蒂尔病(全身性幼年类风湿性关节炎)。每个患者都有持续性的瘙痒性皮疹，角化不良的组织病理学表现局限于表皮的上层，以及稀疏的含有散布的中性粒细胞的浅表真皮浸润物。结论：这些病例证实了斯蒂尔病持续性丘疹和斑块的典型临床和组织病理学表现，表明这种皮疹在成人和青少年组中都有可能发生。
Background: 'Persistent pruritic papules and plaques' of Still's disease represents a recently described eruption seen in a subset of patients. Most cases reported in the literature to date have been associated with adult-onset Still's disease.Methods: We present the clinical and histopathologic examinations of three female patients ranging in age from 15 to 54 years.Results: Our three patients each presented with clinical findings consistent with Still's disease. The youngest patient suffered from the juvenile form of Still's disease (systemic-onset juvenile rheumatoid arthritis). Each patient had a persistent, pruritic eruption with histopathologic findings of dyskeratosis confined to the upper layers of the epidermis as well as a sparse superficial dermal infiltrate containing scattered neutrophils.Conclusions: These cases confirm the characteristic clinical and histopathologic findings of 'persistent papules and plaques of Still's disease' and show the potential for this eruption in both the adult and juvenile age groups.