Evidence for the changes of antitumor immune response during lymph node metastasis in head and neck squamous cell carcinoma

Evidence for the changes of antitumor immune response during lymph node metastasis in head and neck squamous cell carcinoma
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DOI：
10.1016/j.tripleo.2010.03.030
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发表时间：
2010-09-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
通讯作者：
Suzuki, Ryuji
Suzuki, Ryuji
中科院分区：
其他
文献类型：
--
作者：
Kumagai, Kenichi;Hamada, Yoshiki;Suzuki, Ryuji

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Objective.本研究旨在探讨头颈部鳞状细胞癌原发灶与转移灶之间的抗肿瘤免疫反应差异。从17例HNSCC患者的组织标本中的肿瘤浸润性淋巴细胞的克隆性进行了检查，关于他们的T细胞受体（TCR）的剧目和他们的互补决定区3（CDR 3）的大小谱。采用实时定量聚合酶链反应检测细胞因子表达谱和T细胞表型。由TCR库反映的宿主对HNSCC细胞的免疫应答在原发性肿瘤和转移性淋巴结之间不同。转移淋巴结和非转移淋巴结中CD 8（+）-T细胞和T辅助细胞1型（T（H）1）/T细胞毒性1型（T（C）1）细胞因子的产生相似。HNSCC细胞的抗肿瘤免疫应答在淋巴结转移过程中发生变化，HNSCC细胞可逃避CD 8（+）-T细胞和T（H）1/T（C）1细胞介导的细胞毒免疫应答。这些结果表明，淋巴结转移可能与原发性肿瘤抗原的性质变化有关。(Oral《口腔外科医学》《口腔病理学》《口腔放射学》，2010年;110：341-350）
Objective. This study aimed to elucidate the differences in antitumor immune responses between primary tumors and metastatic regional lymph nodes in head and neck squamous cell carcinoma (HNSCC).Study design. The clonality of tumor-infiltrating lymphocytes in tissue specimens from 17 HNSCC patients was examined regarding their T-cell receptor (TCR) repertoires and their complementary determining region 3 (CDR3) size spectratyping. Cytokine expression profiles and T-cell phenotypes also were measured by using real-time quantitative polymerase chain reaction.Results. The host immune responses to HNSCC cells, reflected by the TCR repertoire, differed between primary tumors and metastatic lymph nodes. CD8(+)-T cells and T helper type 1 (T(H)1)/T cytotoxic 1 (T(C)1) cell cytokine production in metastatic and nonmetastatic lymph nodes were similar.Conclusions. The antitumor immune response to HNSCC cells changes during lymph node metastasis, and HNSCC cells can escape the cytotoxic immune responses mediated by CD8(+)-T cells and T(H)1/T(C)1 cells. These results suggest that lymph node metastasis might be associated with changes in the nature of the primary tumor antigens. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;110:341-350)