Coupling of the left ventricular and arterial system.
Coupling of the left ventricular and arterial system.
复制标题
左心室和动脉系统的耦合。
DOI：
10.1007/bf02518919
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发表时间：
1994
影响因子：
3.2
通讯作者：
Cheng,CP
中科院分区：
文献类型：
--
作者：
Little,WC;Cheng,CP
我们研究了耦合的左心室（LV）和动脉系统在8个清醒的狗，仪器测量LV压力和确定LV容量从三个超声确定的尺寸。左室收缩末期压（PES）-容积（VES）关系由腔静脉闭塞测定。将其斜率（EES）与动脉弹性（EA）进行比较，确定为PES/每搏输出量。静息时，反射完整，EES/EA为0.9±0.20。苯异丙胺、硝普钠、多巴酚丁胺等不同剂量的静脉滴注可使EES/EA在0.18-2.59的范围内变化。当EES/EA=0.99±0.15时，在恒定变力状态和舒张末期容积下出现最大LV SW。然而，当EES/EA在0.56和2.29之间时，SW在其最大值的20%以内。当EES/EA降至0.59以下时，SW急剧下降。观察到的SW与EES/EA关系的形状与通过线性LV PES-VES和动脉PES-每搏输出量关系的理论考虑预测的形状相似。我们的结论是，当EES和EA相等时，LV和动脉系统在恒定的VED下产生最大SW;然而，SW与EES/EA的关系有一个宽的平台。
We investigated the coupling of the left ventricle (LV) and the arterial system in eight conscious dogs, instrumented to measure LV pressure and determine LV volume from three ultrasonically determined dimensions. The LV end-systolic pressure (PES)-volume (VES) relation was determined by caval occlusion. Its slope (EES) was compared to the arterial elastance (EA), determined as PES/stroke volume. At rest, with intact reflexes, EES/EAwas 0.9±0.20. EES/EAwas varied over a wide range (0.18–2.59) by the infusion of graded doses of phenylephrine and nitroprusside and dobutamine. Maximum LV SW, at constant inotropic state and end-diastolic volume, occurred when EES/EA=0.99±0.15. However, SW was within 20% of its maximum value when EES/EAwas between 0.56 and 2.29. As EES/EAdecreased below 0.59, SW fell precipitously. The shape of the observed relation of SW to EES/EAwas similar to that predicted by the theoretical consideration of linear LV PES-VESand arterial PES-stroke volume relations. We conclude that the LV and arterial system produce maximum SW at constant VEDwhen EESand EAare equal; however, the relation of SW to EES/EAhas a broad plateau.