Magnetic resonance imaging and histologic evidence of postoperative back muscle injury in rats
Magnetic resonance imaging and histologic evidence of postoperative back muscle injury in rats
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DOI：
10.1097/00007632-200004150-00008
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发表时间：
2000-04-15
期刊：
影响因子：
3
通讯作者：
Kimura, T
中科院分区：
文献类型：
--
作者：
Gejo, R;Kawaguchi, Y;Kimura, T
研究设计。通过磁共振成像和组织学分析评估大鼠术后背部肌肉损伤。目的。将大鼠背部肌肉损伤的磁共振成像表现与组织学结果进行比较，并随后阐明人类术后背部肌肉 T2 加权图像上高强度区域的组织病理学表现。背景数据摘要。之前的一项研究发现，术后腰肌损伤的患者，尤其是手术时间较长的患者，术后背部肌肉的T2加权图像信号强度增加。然而，导致 TS 加权图像上高信号强度的具体组织病理学变化仍不清楚。方法。将大鼠分为三组：假手术组、回缩1小时组、回缩2小时组。术前、术后2、7、21天对多裂肌进行磁共振成像和组织学检查。结果。 TP 加权成像比 T1 加权成像更适合估计背部肌肉损伤。仅在 2 小时回缩组中，T2 加权图像上多裂肌的高信号强度在术后 21 天仍保持。组织学上，1小时回缩组术后21天多裂肌再生完成，但P小时回缩组再生肌纤维直径较小，细胞外液空间仍较大。结论。术后多裂肌再生期 T2 加权图像上的高信号强度可能是由于细胞外间隙增加和肌纤维再生不完全所致。
Study Design. Postoperative back muscle injury was evaluated in rats by magnetic resonance imaging and histologic analyses.Objective. To compare the magnetic resonance imaging manifestation of back muscle injury with the histologic findings in rats and to subsequently clarify the histopathologic appearance of the high intensity regions on T2-weighted images in human postoperative back muscles.Summary of Background Data. In a previous study, it was found that the signal intensity on T2-weighted images of the postoperative back muscles was increased in patients who had postsurgical lumbar muscle impairment, especially in those with a prolonged surgery duration. However, the specific histopathologic changes that clause the high signal intensity on TS-weighted images remain unclear.Methods. Rats were divided into three groups: sham operation group, 1-hour retraction group, and 2-hour retraction group. Magnetic resonance imaging and histology of the multifidus muscles were examined before surgery and at 2, 7, and 21 days after surgery.Results. TP-weighted imaging was more useful than T1-weighted imaging to estimate back muscle injury. The high signal intensity of the multifidus muscles on T2-weighted images remained 21 days after surgery only in the 2-hour retraction group. Histologically, the regeneration of the multifidus muscles was complete at 21 days after surgery in the 1-hour retraction group, but the regenerated muscle fibers in the P-hour retraction group had a small diameter, and the extracellular fluid space remained large.Conclusion. The high signal intensity on T2-weighted images of the postoperative multifidus muscles in the regenerative phase may be due to an increased extracellular space and incomplete muscle fiber regeneration.