Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules
Pilot study trialling a new ambulatory method for the clinical assessment of regional gastrointestinal transit using multiple electromagnetic capsules
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DOI：
10.1111/nmo.12461
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发表时间：
2014-12-01
影响因子：
3.5
通讯作者：
Krogh, K.
中科院分区：
文献类型：
--
作者：
Haase, A. M.;Gregersen, T.;Krogh, K.
背景胃肠道（GI）运动障碍常累及消化道多个区域.因此，简单和安全的评估整个肠道和区域运动是有价值的更精确的诊断。3D-Transit是一种基于可摄入电磁胶囊解剖定位的动态评估总和局部胃肠道通过时间（GITT）的新方法。本研究的主要目的是测试的性能的3D-过境system.MethodsTwenty健康志愿者每人摄入三个电磁胶囊在一段时间内的连续两天。标准的不透射线标记物（ROM）也被摄入，以评估与两种方法获得的总GITT之间的协议。Key ResultsInvestigations耐受性良好，三个胶囊可以同时跟踪最小的数据丢失（胶囊1：中位数：0.2%的时间（范围0-25.3%）。确定区域特异性收缩模式，并用于计算所有受试者的总GITT和区域GITT。总GITT的观察者间一致性为100%（中位变异0%），但区域GITT的一致性较低。总的和区域GITT的逐日和日变化是显着的。3D运输胶囊评估的总GITT与标准ROM（斯皮尔曼rho=0.7）评估的GITT中度相关。结论与推论3D运输是一种耐受性良好的微创非卧床方法，用于评估胃肠道动力。通过提供总的和区域的通过时间，3D-Transit系统为未来健康和疾病中GI功能的临床研究带来了巨大的希望。
BackgroundGastrointestinal (GI) motor disorders often involve several regions of the GI tract. Therefore, easy and safe assessment of whole gut and regional motility is valuable for more precise diagnosis. 3D-Transit is a novel method for ambulatory evaluation of total and regional gastrointestinal transit times (GITT) based on the anatomical localization of ingestible electromagnetic capsules. The main purpose of this study was to test the performance of the 3D-Transit system.MethodsTwenty healthy volunteers each ingested three electromagnetic capsules over a period of two consecutive days. Standard radio-opaque markers (ROM) were also ingested to assess the agreement between total GITT obtained with both methods.Key ResultsInvestigations were well-tolerated and three capsules could be tracked simultaneously with minimal data loss (Capsule 1: median: 0.2% of time (range 0-25.3%). Region specific contraction patterns were identified and used for computation of total and regional GITT in all subjects. Inter-observer agreement was 100% for total GITT (median variation 0%) but less for regional GITT. Day-to-day and diurnal variations were significant for total and regional GITT. Total GITT assessed by 3D-Transit capsules were moderately well-correlated to those assessed with standard ROM (Spearman's rho=0.7).Conclusions & Inferences3D-transit is a well-tolerated and minimal invasive ambulatory method for assessment of GI motility. By providing both total and regional transit times, the 3D-Transit system holds great promise for future clinical studies of GI function in health and disease.