Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases.
Role of the Cysteinyl Leukotrienes in the Pathogenesis and Progression of Cardiovascular Diseases.
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DOI：
10.1155/2017/2432958
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发表时间：
2017
影响因子：
4.6
通讯作者：
Castiglioni L
中科院分区：
文献类型：
--
作者：
Colazzo F;Gelosa P;Tremoli E;Sironi L;Castiglioni L
半胱氨酰白三烯（CysLTs）是由花生四烯酸通过5 - 脂氧合酶（5 - LO）途径合成的强效脂质炎症介质。由于其特性，CysLTs在炎症的发病机制中起着至关重要的作用；因此，作为合成抑制剂或受体拮抗剂的CysLT调节剂在哮喘治疗中至关重要，可能成为治疗其他炎症性疾病（如心血管疾病）的潜在靶点。在心血管疾病中发现5 - LO途径被激活，其介质和受体表达增加。此外，使用CysLT调节剂所观察到的心脏保护作用很有前景，有助于阐明CysLTs与心血管疾病之间的联系。本综述的目的是总结目前关于CysLTs在动脉粥样硬化和心肌梗死的发病机制及进展中作用的研究现状。
Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, central in asthma management, may become a potential target for the treatment of other inflammatory diseases such as the cardiovascular disorders. 5-LO pathway activation and increased expression of its mediators and receptors are found in cardiovascular diseases. Moreover, the cardioprotective effects observed by using CysLT modifiers are promising and contribute to elucidate the link between CysLTs and cardiovascular disease. The aim of this review is to summarize the state of present research about the role of the CysLTs in the pathogenesis and progression of atherosclerosis and myocardial infarction.