Increasing number of components of the metabolic syndrome and cardiac structural and functional abnormalities--cross-sectional study of the general population.
Increasing number of components of the metabolic syndrome and cardiac structural and functional abnormalities--cross-sectional study of the general population.
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DOI：
10.1186/1471-2261-7-17
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发表时间：
2007-06-07
影响因子：
2.1
通讯作者：
Barros, Henrique
中科院分区：
文献类型：
--
作者：
Azevedo, Ana;Bettencourt, Paulo;Barros, Henrique
背景技术背景：我们的目的是评估我们是否可以确定一个分级之间的关联越来越多的组件的代谢综合征和心脏结构和功能异常的预测冠心病的风险独立的Fragmentary risk scores.METHODS：我们进行了一项横断面研究的随机样本的城市人口的波尔图年龄在45岁或以上。共纳入684名参与者。通过与医生的结构化临床访谈、ECG和经胸M型和2D超声心动图收集数据。根据ATPIII-NCEP定义代谢综合征。代谢综合征的特征数量与心脏结构和功能异常之间的关联通过3个多变量回归模型进行评估：调整年龄和性别，调整Fracket风险评分预测的10年冠心病风险，调整年龄、性别和收缩压。代谢综合征的特征数量与心脏结构和功能参数之间存在正相关，在调整年龄和性别时，所有心脏变量的趋势一致且具有统计学意义。当以Fracket评分作为自变量考虑冠心病10年预测风险时，左心室几何构型、左心房直径和舒张功能障碍参数保持了这一趋势，而左心室收缩功能障碍则没有。左心室舒张功能障碍的患病率，平均左心室质量，左心室直径和左心房直径增加显着的代谢综合征的功能的数量时，另外调整收缩压作为一个连续variable.CONCLUSION：增加代谢综合征的严重程度与日益受损的结构和功能的心脏。这种关联独立于心脏舒张功能障碍间接指标的Fragrance风险评分，而不是收缩功能障碍，并且不能用血压水平来解释。
BACKGROUND: We aimed to assess whether we could identify a graded association between increasing number of components of the metabolic syndrome and cardiac structural and functional abnormalities independently of predicted risk of coronary heart disease by the Framingham risk score.METHODS: We conducted a cross-sectional study on a random sample of the urban population of Porto aged 45 years or over. Six hundred and eighty-four participants were included. Data were collected by a structured clinical interview with a physician, ECG and a transthoracic M-mode and 2D echocardiogram. The metabolic syndrome was defined according to ATPIII-NCEP. The association between the number of features of the metabolic syndrome and the cardiac structural and functional abnormalities was assessed by 3 multivariate regression models: adjusting for age and gender, adjusting for the 10-year predicted risk of coronary heart disease by Framingham risk score and adjusting for age, gender and systolic blood pressure.RESULTS: There was a positive association between the number of features of metabolic syndrome and parameters of cardiac structure and function, with a consistent and statistically significant trend for all cardiac variables considered when adjusting for age and gender. Parameters of left ventricular geometry patterns, left atrial diameter and diastolic dysfunction maintained this trend when taking into account the 10-year predicted risk of coronary heart disease by the Framingham score as an independent variable, while left ventricular systolic dysfunction did not. The prevalence of left ventricular diastolic dysfunction, and the mean left ventricular mass, left ventricular diameter and left atrial diameter increased significantly with the number of features of the metabolic syndrome when additionally adjusting for systolic blood pressure as a continuous variable.CONCLUSION: Increasing severity of metabolic syndrome was associated with increasingly compromised structure and function of the heart. This association was independent of Framingham risk score for indirect indices of diastolic dysfunction but not systolic dysfunction, and was not explained by blood pressure level.