Chlamydophila abortus infection in the mouse: A useful model of the ovine disease
Chlamydophila abortus infection in the mouse: A useful model of the ovine disease
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DOI：
10.1016/j.vetmic.2008.09.029
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发表时间：
2009-03-16
影响因子：
3.3
通讯作者：
Salinas, J.
中科院分区：
文献类型：
--
作者：
Caro, M. R.;Buendia, A. J.;Salinas, J.
Chlamaprophila（C.）流产杆菌是一种专性细胞内细菌，能够在几种哺乳动物的胎盘上定植，可能在妊娠的最后三分之一引起流产。这种感染主要影响小型反刍动物，导致世界范围内农业的重大经济损失。此外，据报道，怀孕的农民或屠宰场工人有感染人畜共患病的风险。小鼠模型已被广泛用于研究疾病的病理学和免疫细胞在控制感染中的作用。此外，这种动物实验模型已被认为是一种有用的工具，以评估新的候选疫苗和佐剂，可以防止流产和减少胎儿死亡。利用这些模型的未来研究将提供并揭示关于抗C.流产，并将增加对知之甚少的问题，如衣原体持久性的知识。(C)2008 Elsevier B.V.保留所有权利。
Chlamydophila (C.) abortus is an obligate intracellular bacterium able to colonize the placenta of several species of mammals, which may induce abortion in the last third of pregnancy. The infection affects mainly small ruminants resulting in major economic losses in farming industries worldwide. Furthermore, its zoonotic risk has been reported in pregnant farmers or abattoir workers. Mouse models have been widely used to study both the pathology of the disease and the role of immune cells in controlling infection. Moreover, this animal experimental model has been considered a useful tool to evaluate new vaccine candidates and adjuvants that could prevent abortion and reduce fetal death. Future studies using these models will provide and reveal information about the precise mechanisms in the immune response against C. abortus and will increase the knowledge about poorly understood issues such as chlamydial persistence. (C) 2008 Elsevier B.V. All rights reserved.