Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design
Understanding Lung Immunopathology Caused by the Human Metapneumovirus: Implications for Rational Vaccine Design
复制标题
DOI：
10.1615/critrevimmunol.2015013844
复制
发表时间：
2015-01-01
影响因子：
1.3
通讯作者：
Bueno, Susan M.
中科院分区：
文献类型：
--
作者：
Palavecino, Christian E.;Cespedes, Pablo F.;Bueno, Susan M.
急性呼吸道感染(ARTIS)是全世界儿童死亡的主要原因。人类偏肺病毒(HMPV)是导致儿童肺炎住院的主要原因之一。宿主对hMPV产生的获得性免疫反应通常在预防再次感染方面效率低下，从童年到老年，这种感染在一生中重复出现。尽管进行了大量的研究工作，但到目前为止，还没有获得许可的疫苗来预防由hMPV感染引起的呼吸道疾病。在这篇文章中，我们回顾了目前在动物模型中测试的疫苗策略，以及这些研究在理解不同免疫细胞群对hMPV清除以及预防和解决暴露于病毒后的肺部炎症方面的意义。
Acute respiratory tract infections (ARTIs) are the major cause of child mortality worldwide. The human metapneumovirus (hMPV) is one of the leading causes of child hospitalizations due to pneumonia. The adaptive immune response generated by the host against hMPV is usually inefficient at protecting from reinfections, which is repeat throughout life, from childhood to old age. Despite considerable research efforts, to date there are no licensed vaccines to prevent respiratory disease caused by hMPV infection. In this article we review current vaccine strategies tested in animal models and the implication of such studies in understanding the different immune cell populations that contribute to hMPV clearance and the prevention and resolution of lung inflammation upon exposure to the virus.