Serum ceruloplasmin and the risk of cancer in Finland.
Serum ceruloplasmin and the risk of cancer in Finland.
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DOI：
10.1038/bjc.1992.58
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发表时间：
1992-02
影响因子：
8.8
通讯作者：
Teppo, L
中科院分区：
文献类型：
--
作者：
Knekt, P;Aromaa, A;Maatela, J;Rissanen, A;Hakama, M;Aaran, R K;Nikkari, T;Hakulinen, T;Peto, R;Teppo, L
通过一项病例对照研究，研究了血清铜蓝蛋白水平与癌症发病率的关系。这项研究嵌套在一项纵向研究中，研究对象为39268名芬兰人，他们参加了1968-1972年间社会保险机构流动诊所健康体检调查。在中位数8年的随访中，766例癌症病例被确定。铜蓝蛋白水平是从这些癌症病例和每个病例两个匹配对照的基线收集的存储血清样本中测定的。癌症的总发病率与血清铜蓝蛋白水平呈正相关。肺癌和其他与吸烟相关的癌症的关联性最强，因此在男性中也是如此。与血清铜蓝蛋白水平最低的五分之一相比，吸烟调整后的男性患肺癌的相对危险度为4.3(95%可信区间=1.8-10.6)。与吸烟有关的癌症合并的相对危险度为3.9(CI=1.9~8.4)，与吸烟无关的癌症的相对危险度为0.9(CI=0.6~1.5)。在进一步调整了几个潜在的混杂因素，如血清维生素A、维生素E和硒的水平后，高浓度血清铜蓝蛋白导致肺癌风险增加的情况仍然存在。在随访的前6年中，风险比后来的风险更大，在前2年的风险最大。因此，对目前结果最有可能的解释是，肺癌患者血清铜蓝蛋白水平升高主要是由于隐匿性癌症。
The relationship between serum ceruloplasmin level and cancer incidence was investigated in a case-control study nested within a longitudinal study of 39,268 Finns participating in the Social Insurance Institution's Mobile Clinic Health Examination Survey carried out in 1968-1972. During a median follow-up of 8 years, 766 cancer cases were identified. Ceruloplasmin levels were determined from stored serum samples collected at the baseline from these cancer cases and from two matched controls per case. The overall incidence of cancer was positively associated with serum ceruloplasmin level. The association was strongest for lung cancer and other cancers related to smoking and, consequently, in males. The smoking-adjusted relative risk of lung cancer among men was 4.3 (95% confidence interval (CI) = 1.8-10.6) in the highest quintile of serum ceruloplasmin as compared with that in the lowest quintile. The corresponding relative risks for cancers related to smoking combined, and for cancers not related to smoking were 3.9 (CI = 1.9-8.4) and 0.9 (CI = 0.6-1.5), respectively. The elevated risk of lung cancer at high concentrations of serum ceruloplasmin persisted after further adjustment for several potential confounding factors such as serum levels of vitamins A and E and selenium. The risk was stronger during the first 6 years of follow-up than later, and strongest during the first 2 years. The most likely explanation of the present results thus is that high serum ceruloplasmin levels in lung cancer are mainly due to occult cancer.